GENETIC APPROACHES TO NEUROPHARMACOLOGY OF ETHANOL

此申请是为了继续科罗拉多大学的酒精 研究中心 该中心自2000年以来一直正式存在。 NIAAA中心计划于1977年重新启动。 协调中心 利用遗传技术提供动物模型， 在分子水平上解开乙醇作用的秘密。 作为 作为这些研究的必然结果，我们还利用遗传技术， 研究乙醇对人类受试者的影响， 基因在人类酗酒中的作用 虽然这两个领域 是密切相关的，这一直是一个指导原则，动物 遗传学研究作为研究基本行为的工具是有价值的 无论基因多态性在动物中是否如此有用， 存在于人类。

This application is to continue the University of Colorado Alcohol Research Center. This Center has been in formal existence since the NIAAA Centers program was re-initiated in 1977. Consistently the Center has utilized genetic techniques to provide animal models with which to unlock the secrets of the action of ethanol at a molecular level. As a corollary to these studies we have also utilized genetic techniques to investigate the effect of ethanol in human subjects and to investigate the role of genetics in human alcoholism as well. While these two areas are closely related, it has always been a guiding principle that animal genetic studies are valuable as tools to investigate fundamental actions of ethanol, whether or not the genetic polymorphisms so useful in animals exist in humans.