STRUCTURE/FUNCTION CORRELATIONS IN TISSUE GAS EXCHANGE

总体目标是更好地理解结构-功能 肌肉对血液组织的设计和能力中的相互作用 交换。我们开发了一些方法来评估肌肉的几个方面 毛细纤维形态计量学。我们将培训学生使用这些工具 方法结合毛细血管的组织化学特征 应用异质性研究心肌氧流量和心肌结构容量 研究其极限与纤维需氧量的关系。这个项目将 重点放在老鼠和兔子的心脏上，与鸟类和蝙蝠进行比较 探索肌肉有氧能力和程度的自然差异 毛细作用。我们的中心假设是它的大小 决定氧气的是毛细管-纤维界面，而不是扩散距离 有氧肌肉中的流量速率。在高有氧心肌中的数据将 与我们正在进行的骨骼肌研究具有重要的相关性 纤维类型分布、聚集性和有氧性差异较大 能力，包括陆生哺乳动物的运动肌和飞行 鸟类和蝙蝠的肌肉。它应该为我们提供关于 了解肌肉结构-功能相关性的关键因素 血液组织转移的能力，应该有助于理解 以及人类对受损组织氧合反应的管理。

The overall objective is to better understand structure-function interactions in the design and capacity of muscles for blood-tissue exchange. We developed methods to assess several aspects of muscle capillary-fiber morphometrics. We will train students to use these methods, together with histochemical characterization of capillary heterogeneity to explore myocardial structural capacity for O2 flux and study its limit in relation to fiber oxygen demand. This project will focus on rat and rabbit heart, with comparison with birds and bats to explore natural differences in muscle aerobic capacity and degree of capillarization. Our central hypothesis is that it is the size of the capillary-fiber interface, not diffusion distances, which determine O2 flux rates in aerobic muscles. Data in the highly aerobic myocardium will be important correlates to our ongoing studies of skeletal muscles with large differences in fiber type distribution, clustering and aerobic capacity, including locomotory muscles of terrestrial mammals and flight muscles in bird and bat. It should provide new insights in the understanding of key aspects of structure-function correlations in muscle capacity for blood-tissue transfer, and should help in the understanding and management of human response to impaired tissue oxygenation.