CORE--CYCLOTRON/ RADIOCHEMISTRY

回旋加速器/放射化学核心提供所有的放射性核素， 放射性前体和经批准的PET放射性药物 这项计划资助的研究和临床项目。这包括 为项目1生产氟-18和碳-11前体，以及 [11C]氟马西尼、[11C]N-哌啶基苯甲酸酯、 [11C]拉氯必利、[11C]甲氧基四苯肼和5-[123I]碘代苯并阿米考 对于项目2-4。PET放射性核素的生产是使用专用的 回旋加速器公司CS-30回旋加速器，配备10个回旋加速器目标，8个 它们位于垂直的横梁梯子上。主要和次要 所有放射性核素都有生产目标。全回旋加速器 目标、机械、电气和计算机系统 内部建造；核心提供所有例行和紧急维修 所有这些系统，以及回旋加速器本身。 PET放射性药物的放射化学研究及常规生产 是在一个设备齐全的放射化学实验室里进行的，这个实验室有 提供临床剂量的碳-11放射性药物的能力 以不到1小时的间隔按顺序排列。所有的合成都完成了 由CORE设计、建造和维护的远程使用设备 工作人员。核心提供在放射化学方面的成熟专业知识， 辐射安全、质量控制和法规文件 批准。

The Cyclotron/Radiochemistry Core provides all of the radionuclides, radioactive precursors, and approved PET radiopharmaceuticals for the research and clinical projects of this Program Grant. This includes production of fluorine-18 and carbon-11 precursors for Project 1, and routine deliveries of (11C]flumazenil, [11C]N-methylpiperidylbenzilate, [11C]raclopride, [11C]methoxytetrabenazine and 5-[123I]iodobenzovesamicol for Projects 2-4. PET radionuclide production is done using a dedicated Cyclotron Corp. CS-30 cyclotron, outfitted with 10 cyclotron targets, 8 of which are located on a vertical beam ladder. Primary and secondary production targets are available for all radionuclides. All cyclotron targetry, mechanical, electrical and computer systems have been constructed in house; the Core provides all routine and emergency repairs for all of these systems, as well as for the cyclotron itself. Radiochemical research and routine production of PET radiopharmaceuticals is done in a well-equipped radiochemistry laboratory, which has the capability to deliver clinical doses of carbon-11 radiopharmaceuticals in sequential fashion at less than 1 hour intervals. All syntheses are done remotely using apparatus designed, constructed and maintained by Core staff members. The Core provides established expertise in radiochemistry, radiation safety, quality control, and documentation for regulatory approvals.