MULTIMODALITY FUNCTIONAL BRAIN IMAGING

脑功能成像是基于这样的假设， 脑循环的局部变化（即，血流，血液 体积、血管平均通过时间）和代谢准确 反映神经元活动的变化。 正电子发射断层扫描 (PET)和磁共振成像（MRI）能够测量 安全准确地改变循环和代谢， 提供了一个了解人脑功能的独特窗口 但我们的 了解脑循环与 神经元活动的代谢是不完全的， 了解PET和MRI各自的作用， 调查这些问题。 本项目的目的是 将PET、MRI和磁共振波谱（MRS）结合使用 在正常人类受试者以及患有选定疾病的患者中 为了更全面地了解 获得的信号和PET将发挥的各自作用， MRI在脑功能成像中的应用 该项目称赞工作在 该项目由权力，详细探讨了关系， 大脑功能的交付，运输和代谢 葡萄糖 这一项目也将是重要的工作， Peterson的项目，其中MRI的作用尚未确定。 最后，这个项目汇集了专业知识和资源， 3个主要研究小组，他们在功能性 PET脑成像（Raichle an Powers）、MRI（Haacke and Lin） 和MRS（阿克曼，尼尔和布雷特霍斯特）是独一无二的，应确保 关于人类大脑的重要新科学信息 功能将从拟议的研究中获得。

Functional brain imaging is based upon the assumption that localized changes in brain circulation(i.e., blood flow, blood volume, vascular mean transit time) and metabolism accurately reflect changes in neuronal activity. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are able to measure changes in circulation and metabolism safely and accurately to provide a unique window into human brain function. However, our understanding of the relationship of brain circulation and metabolism to neuronal activity is incomplete as is our understanding of the respective roles of PET and MRI in investigating these issues. It is the purpose of this project to employ PET, MRI and magnetic resonance spectroscopy (MRS) together in normal human subjects as well as patients with selected diseases to obtain a more complete understanding of the basis for the signals obtained and the respective role to be played by PET and MRI in functional brain imaging. This project compliments work in the project by powers which explores in detail the relationship of brain function to the delivery, transport and metabolism of glucose. This project will also be important to the work in the project by Peterson where the role of MRI has yet to be determined. Finally, this project brings together the expertise and resources of 3 major research groups whose combined experience in functional brain imaging with PET (Raichle an Powers), MRI (Haacke and Lin) and MRS (Ackerman, Neil and Bretthorst) is unique and should ensure that significant new scientific information regarding human brain function will be forthcoming from the proposed studies.