NATURAL CONTROL OF M AVIUM IN SAIDS

M. SAIDS群体中的禽流感感染（MAI） 从1988年无法检测到的水平增加到近年来的18-25%。 这种机会性感染可引起腹泻、恶病质和 有时在严重免疫功能低下的猴子中出现肺炎， 与艾滋病儿童的MAI有着显著的相似性。 我们检测到M。 通过培养和PCR鉴定禽流感的分离株， 环境（土壤和水）和猴子的分子指纹图谱 分析. 到目前为止，从环境中分离的菌株很少感染深层 猴子的组织。 猴巨噬细胞的体外试验 证明了SIV和一种常见的 致病M.在我们的猴子群体中发现的鸟类产生的 预期的病毒水平。 我们致病菌株的蛋白质成分 正在被定性。

The incidence of M. avium infection (MAI) in the SAIDS colony has increased from undetectable levels in 1988 to 18-25% in recent years. This opportunistic infection produces diarrhea, cachexia, and sometimes pneumonia in severely immunocompromized monkeys with remarkable similarity to MAI in children with AIDS. We detect M. avium by culture and PCR and characterize isolates from the environment (soil and water) and monkeys by molecular fingerprint analysis. To date, isolates from the environment rarely infect deep tissues of monkeys. In vitro testing of monkey macrophages demonstrates that cells co-infected with SIV and a common strain of pathogenic M. avium found in our monkey colony produces higher than expected levels of virus. Protein components of our pathogenic strain are being characterized.