CENTRAL AND PERIPHERAL EFFECTS OF BIPERIDEN AND TRIHEXYPHENIDYL

这是一项双盲、安慰剂对照、随机、交叉研究 为了确定两种常用药物的中枢和外周效应， 抗胆碱能药物（比哌立登和苯海索）在15例正常 志愿者 抗胆碱能药物常用于治疗急性发作 精神分裂症患者中抗精神病药引起的运动障碍。 一个 抗胆碱能药物，其表现出更高的中枢与 外周抗胆碱作用在该组中是有利的 病人。

This is a double-blind, placebo-controlled, randomized, cross-over study to determine the central and peripheral effects of two commonly used anticholinergic agents (biperiden and trihexyphenidyl) in 15 normal volunteers. Anticholinergic agents are often used to treat acute onset neuroleptic-induced movement disorders in schizophrenic patients. An anticholinergic agent that exhibits a higher ratio of central to peripheral anticholingeric effects would be advantageous in this group of patients.