PET EVALUATION OF NEUROENDOCRINE TUMORS AND OTHER TUMORS OF CHILDHOOD

正电子发射断层扫描（PET）是一种非侵入性的医学成像技术 一种利用专门示踪剂描绘生理和病理特征的技术， 和病理生理过程。 这项建议的目的是适用于 PET技术用于检测、表征和评估 交感神经源性肿瘤的治疗反应 这些肿瘤和其他实体恶性肿瘤， 孩子 我们希望通过上级图像分辨率 PET技术，预计系列研究将表明， 肿瘤摄取的变化反映了组织对治疗的反应， 作为治疗效果或失败的早期指标。 如果这样 信息可以通过PET扫描非侵入性地获得， 对肿瘤患者的管理可以得到实质性的改善。

Positron emission tomography (PET) is a non-invasive medical imaging technique which utilizes specialized tracers to depict both physioligic and pathophysiologic processes. The aim of this proposal is to apply PET technology for the detection, characterization, and assessment of the response to therapy of tumors derived from the sympathetic nervous system in adults, and these tumors and other solid malignancies in children. We expect to show, by virtue of the superior image resolution of PET technology, it is anticipated that serial studies will show that changes in tumor uptake reflect the tissue response to treatment and serve as an early indicator of therapeutic efficacy or failure. If such information can be made available noninvasively by PET scanning, the management of patients with tumors could be substantially improved.