PILOT TRIAL TO ASSESS IMMUNE STATUS IN CHILDREN WITH CHRONIC HEPATITIS B

患有慢性乙肝的儿童参加了这项试点 研究试图更好地理解潜在的细胞 乙肝病毒在体内清除的机制 患有慢性乙肝的儿童。有些孩子会 接受α-2b干扰素治疗4-6个月。评估 体内产生促炎细胞因子，包括白介素1- β、肿瘤坏死因子-BP和白介素8将被检测 L的稳定终端产品-精氨酸/硝酸盐-也将是前瞻性的 氧化物生物合成途径。此外，血清中的HBeAg抗体和 将用更灵敏的实验免疫分析法检测乙肝表面抗原。

Children with chronic hepatitis B infection are enrolled in this pilot study in an attempt to better understand the underlying cellular mechanisms responsible for clearance of the hepatitis B virus in children with chronic hepatitis B infection. Some of the children will undergo therapy with alpha-2b interferon for 4-6 months. Evaluation of in-vivo production of proinflammatory cytokines including interleukin one- beta, tumor necrosis factor-bp, and interleukin eight will be assayed prospectively as will the stable end-products of the L-arginine/nitric oxide biosynthetic pathway. In addition, serum antibodies to HBeAg and HBsAg will be assayed with a more sensitive experimental immunoassay.