ANTIDEPRESSANT EFFECTS ON REGIONAL CEREBRAL BLOOD FLOW IN OCD

这项研究考察了两种不同的抗抑郁药物的效果，一种是 5-羟色胺再摄取抑制剂和另一种去甲肾上腺素再摄取 抑制抑郁和强迫症状。SPECT扫描 在治疗前和治疗结束时检查脑部的变化 与药物和临床核心相关的血流。 17名患者已经完成了这项研究。所有17名患者都有 在服药前和服药12周后进行SPECT扫描 另外三名患者只做了一次扫描，因为 他们在完成研究之前就退出了这项研究。这项研究是 已完成，并对数据进行了分析，并得出了初步结果 提交给1995年12月在圣胡安举行的ACNP会议。 研究已经完成，并对数据进行了分析。这个 发现如下：1)对药物有反应的患者也 表现为rCBF改变(额前区血流减少， 右多于左)。没有改善的患者没有表现出这样的表现 变化。2)随后改善的患者的内侧rCBF较高 额区和尾状核比扫描时没有改善的人更好 在他们接受药物治疗之前。基于这些发现，我们 向NIMH申请拨款。

The study examines the effect of two different antidepressants, one a serotonin reuptake inhibitor and another a norepinephrine reuptake inhibitor on depression and obsessive-compulsive symptoms. SPECT scans taken before and at the end of treatment examined changes in cerebral blood flow related to medication and clinical cores. Seventeen patients have completed the study. All seventeen patients had SPECT scans before medication and after twelve weeks of medication and also had MRI'S. An additional three patients had only one scan because they dropped out of the study before completion. The study is completed and the data have been analyzed with preliminary results presented at the ACNP meeting in San Juan, December 1995. The study has been completed and the data has been analyzed. The findngs are as follows: 1) Patients who responded to medication also showed change of rCBF (reduced blood flow in anterior frontal region, more right than left). Patients who did not improve showed no such change. 2) Patients who subsequently improved had higher rCBF in medial frontal region and caudate than those who did not improve when scanned before they were placed on medication. Based on these findings, we applied for a grant to the NIMH.