METABOLIC EFFECT OF TRP64ARG MUTATION IN BETA 3 ADRENERGIC RECEPTORS IN DIABETES

贝勒医学院和德克萨斯州休斯敦健康科学中心公共卫生学院人类遗传学系的研究人员将研究β肾上腺素能受体激活对患有和不患有非胰岛素依赖型糖尿病(NIDDM)的西班牙裔男性和女性的脂肪和葡萄糖代谢的影响。这些研究的目的是确定在墨西哥裔美国人中，β3-肾上腺素能受体(AR)突变、体脂分布以及脂肪和葡萄糖代谢之间是否存在可预测的关系。通过使用营养和运动作为实验操作，我们计划确定该突变在调节健康的燃料底物代谢中的作用以及它在NIDDM中的失调。

Investigators in Baylor College of Medicine and the Department of Human Genetics at the School of Public Health, Health Sciences Center, Houston, TX will study the effects of beta adrenergic receptor activation on lipid and glucose metabolism in Hispanic men and women with and without non-insulin-dependent diabetes mellitus (NIDDM). The objective of these studies is to determine whether there is a predictable relationship between the beta 3-adrenergic receptor (AR) mutation, body fat distribution and lipid and glucose metabolism in Mexican-Americans. By using nutrition and exercise as experimental manipulations, we plan to determine the role of this mutation in the regulation of fuel substrate metabolism in health and its dysregulation in NIDDM.