EFFECT OF 5 LIPOXYGENASE INHIBITOR ON NASAL POLYPOSIS

鼻息肉病的病理生理复杂，病因不明。鼻息肉常与哮喘、过敏性鼻炎和阿司匹林不耐受并存。主要由嗜酸性粒细胞组成的炎症浸润是大多数鼻息肉的特征，无论病因如何。局部鼻类固醇、全身皮质类固醇和手术切除的标准治疗经常失败。Zileuton已被证明是一种有效的选择性5-脂氧合酶活性抑制剂。改善鼻症状和息肉大小的患者治疗zileuton已经观察到轶事。本研究的目的是比较zileuton和安慰剂治疗鼻息肉病的疗效。

The pathophysiology of nasal polyp disease is complex and the etiology is elusive. Nasal polyps often coexist with asthma, allergic rhinitis and aspirin intolerance. An inflammatory infiltrate primarily composed of eosinophils is characteristic of the majority of nasal polyps regardless of the cause. Standard treatment with topical nasal steroids, systemic corticosteroids and surgical removal ofter fails. Zileuton has been shown to be a potent and selective inhibitor of 5-lipoxygenase activity. Improvement in nasal symptoms and polyp size in patients treated with zileuton has been anectdotally observed. The purpose of this study is to compare the efficacy of zileuton and placebo in nasal polyp disease.