CORE--TISSUE CULTURE

国家发改委组织培养核心实验室收到了 并在过去四年中热情使用，超过40 调查人员利用其服务。实验室已经提供了 有效地促进获取、准备和培养 组织和细胞，这是关键的，但耗时和 皮肤相关研究的昂贵方面。此外， 实验室一直是以下领域讨论的焦点 国家发改委调查人员，直接导致几个新的合作 针对皮肤生物学和老年人疾病的研究项目 皮肤。目标是：1)协助应用现代技术 和方法通过提供皮肤来进行皮肤相关研究 组织和细胞；2)通过以下方式降低皮肤相关研究的成本 使组织/细胞采购系统化和同步化 培养过程；3)确保组织和细胞的质量 研究，和调查人员的安全；4)促进进一步的 以皮肤为导向的部门讨论和协作 研究；以及5)将我们获得的知识应用于基础 以及有关人类皮肤病的临床问题。要实现 这些目标我们将继续：1)作为可靠的来源 皮肤组织(人和小鼠皮肤库)，2)纯化和培养 来自人和小鼠皮肤的不同细胞群，包括 皮肤病患者的标本活检(细胞库)，3) 以经济高效的方式提供广泛的单克隆板 不同细胞类型的抗体和生长因子(抗体 和生长因子库)，4)购买组织培养试剂 大宗数量并建立共享机制，5)监测 组织和细胞的质量，并)提供分离和 培养皮肤细胞。这些服务应该促进皮肤- 面向高质量和缩短时间的研究 费用。这个实验室的广泛使用和 对服务的需求不断增长，对 组织培养核心是组织培养持续发展的关键 国家发改委。

The SDRC Tissue Culture Core Laboratory has received heavy and enthusiastic use during the past four years, with more than 40 investigators utilizing its services. The laboratory has served effectively in facilitating the acquisition, preparation, and culturing of tissue and cells, which are critical, yet time-consuming and expensive aspects of skin-related research. Moreover, the laboratory has served as a focal point for discussions among SDRC investigators, leading directly to several novel collaborative research projects that address skin biology and diseases of the skin. Objectives are to: 1) assist in applying modern technologies and methodologies to skin-related research by providing skin tissue and cells; 2) reduce the costs of skin-related research by systematizing and synchronizing tissue/cell procurement and culturing processes; 3) ensure the quality of tissues and cells being studied, and the safety of investigators; 4) promote further inter- departmental discussion and collaboration on skin-oriented research; and 5) apply the knowledge that we gain to fundamental and clinical questions about skin disease in humans. To achieve these goals we will continue to: 1) serve as a reliable source of skin tissues (Human and Mouse Skin Banks), 2) purify and culture different cell populations from human and mouse skin, including specimens biopsies from patients with skin disease (Cell Bank), 3) provide, in a cost-effective manner wide panels of monclonal antibodies and growth factors for different cell types (Antibody and Growth Factor Banks), 4) purchase tissue culture reagents in bulk quantities and to develop sharing mechanisms, 5) monitor the quality of tissues and cells, and ) provide training in isolating and culturing of cells from skin. These services should promote skin- oriented research of high quality and with reduced time and expense. As evidenced by the extensive use of this laboratory and the growing need for services, the continued support for the Tissue Culture Core is essential for the continued progress of the SDRC.