CORE--CLINICAL

临床核心促进了MADRC的目标和 通过识别男性来满足个人项目的需求 以及患有神经退行性疾病的女性 对痴呆症感兴趣并适合于 参与临床研究。卫星 位于底特律的诊断和治疗中心(SDTC) 在密歇根州北部的农村地区帮助实现了种族上的 居住在农村和城市的不同人群 从最低限度反映疾病的所有严重程度 有症状到严重受损。潜在研究 受试者，包括通过 宾夕法尼亚大学老年病研究与培训中心 密歇根州，被给予全面的医疗和神经学 检查并使用显式诊断进行分类， 包括和排除标准。人口统计数据和 他们神经系统疾病的体征和症状，包括 行为、运动体征和痴呆症的严重程度 以每个诊所的标准化程序为特点 参观。这些受试者中的一个子集，他们命名了一个耐用的 健康决定和表明意愿的授权书 为了获得尸检，纵向跟踪并提供服务 作为检查临床病程的研究资源 疾病与临床病理的相关性。他们会收到 在整个治疗过程中定期进行临床评估 他们的疾病包括对行为的定量评估 和机动标志，并经常通过电话联系， 并提供社会工作和护理服务，以鼓励 继续合作。 核心人员提供患者和护理人员支持， 刺激患者参与研究，而 家属在获取身体脑中的合作 考试。他们协调和监督 患者参与临床研究以确保 适当的主题选择和患者安全 进行了多项研究。核心也协调 其与地方、州和国家方案的活动 阿尔茨海默病，如CERAD。 临床核心还提供关于临床的咨询 痴呆症的方方面面与患者评估和管理 MADRC的项目和其他核心，并获得批准 有其他资金的项目。核心的工作人员也 进行有关医生角色的演讲， 社会工作者和护士在诊断、评估、 老年痴呆症的治疗和管理 MADRC的外展效应。

The Clinical Core promotes the goals of the MADRC and serves the needs of individual projects by identifying men and women with neurodegenerative diseases associated with dementia who are interested in and appropriate to participate in clinical research studies. Satellite Diagnostic and Treatment Centers (SDTC) located in Detroit and in rural northern Michigan help achieve an ethnically diverse population of rural and urban residing subjects who reflect the full range of disease severity from minimally symptomatic to severely impaired. Potential research subjects, including normal controls identified through the Geriatric Research and Training Center at the University of michigan, are given comprehensive medical and neurological examinations and classified using explicit diagnostic, inclusion and exclusion criteria. Demographic data and the signs and symptoms of their neurological disease, including behavior, motor signs and dementia severity, are characterized using standardized procedures at each clinic visit. A subset of these subjects who have named a durable power of attorney for health decisions and indicate a wish to obtain an autopsy are followed longitudinally and serve as a resource for studies examining the clinical course of disease and clinicopathological correlations. They receive periodic clinical evaluations throughout the course of their illness including quantitative assessment of behavior and motor signs, and are contacted frequently by telephone, and furnished social work and nursing services to encourage continued cooperation. Core personnel provide patient and caregiver support that stimulates patient participation in research, and the cooperation of families in obtaining postmortem brain examinations. They coordinate and oversee the participation of patients in clinical research to assure appropriate subject selection and patient safety when multiple studies are performed. The Core also coordinates its activities with local, state and national programs for Alzheimer's disease, such as CERAD. The Clinical Core also provides consultation about clinical aspects of dementia and patient evaluation and management to projects and other cores of the MADRC and to approved projects with other funding. The staff of the Core also conducts presentations concerning the role of physicians, social workers, and nurses in the diagnosis, assessment, treatment and management of dementia for educational and outreach effects of the MADRC.