CORE--CENTRAL VIRUS CULTURE

UAB CFAR运行中央病毒核心(CVC)共享资源 1988年。这个核心的具体目标是：(1)提供专门的- 设计并位于中心位置的BSL 2-3实验室空间通向所有UAB 调查人员使传染性艾滋病毒研究可以受到身体上的限制 到指定区域；(2)提供和维护成本高的设备 核心设施内的基本艾滋病毒研究所需的 促进和扩大所有调查人员的研究能力和 避免设备采购中的冗余；(3)提供持续的 对调查人员及其研究进行培训、监督和监督 关于与CVC进行艾滋病毒研究所需的BSL 2-3实践的工作人员； (4)通过新成立的机构促进艾滋病毒/艾滋病研究的发展 通过向CVC工作人员提供在基础和 致力于这些目标的艾滋病毒临床研究。CVC包括 位于中心位置的两个生物安全2-3级(BSL 2-3)实验室和 他们的相关专业和技术人员。这些实验室是 位于加州大学伯克利分校的中心，在最大的 艾滋病毒研究人员的集中度。它们加起来有2500平方英尺。 BSL 2-3英尺的实验室空间，包括9个独立的100平方英尺 足部组织培养套间。无论是个人文化套件还是 外部公共设备区完全配备了分子， 生物学和临床艾滋病毒研究。核心运行在 核心咨询所确定的具体用法和优先准则 委员会，并遵守NIH/CDC关于安全操作的建议 程序。自1988年资助以来，45名校长的研究 联邦政府资助的调查人员已被安排在这些 设施。目前，CVC支持24名UAB教职员工的研究 代表学院内11个不同的部门和部门 医学。CVC已经培训、监督和协助了105名研究人员 包括研究生、博士后、技术人员和 教职员工。目前，共有活跃的CVC用户。此外 对于R01类型的项目，CVC支持了NIH的重大研究 资助方案项目和授予UAB调查人员的合同自 1988年，包括NCDDG、NCVDG、PEBRA、ACTG、AVEU、NICHD和HIV基因 变型项目。超过300种同行评议的科学出版物已经 自1993年以来在CVC内开展的工作的结果。资金是 要求支持CVC的基本基础设施成本 尽管有大量的按存储容量使用计费系统。

The UAB CFAR has operated a Central Virus Core (CVC) shared resource since 1988. The specific aims of this core are: (1) To provide specially- designed and centrally-located BSL 2-3 laboratory space to all UAB investigators so that infectious HIV research can by physically restricted to specified areas; (2) To provide and maintain the high cost equipment needed for basic HIV research within the core facility in order to facilitate and broaden the research capabilities of all investigators and to avoid redundancy in equipment purchases; (3) To provide ongoing training, supervision, and monitoring of investigators and their research staff regarding BSL 2-3 practices required for HIV research with the CVC; (4) To foster the development of HIV/AIDS research by new and established investigators by providing a CVC staff with broad experience in basic and clinical HIV research which is dedicated to these goals. The CVC consists of two centrally-located biosafety level 2-3 (BSL 2-3) laboratories and their associated professional and technical staff. These laboratories are centrally located on the UAB campus in the vicinity of the greatest concentrations of HIV researchers. Together, they constitute 2500 square feet of BSL 2-3 laboratory space including nine self-contained 100 square foot tissue culture suites. Both the individual culture suites and the outer common equipment areas are completely equipped for molecular, biological, and clinical HIV research. The core is operated under the specific usages and priority guidelines established by the Core's Advisory Committee and complies with NIH/CDC recommendations for safe operating procedures. Since funded in 1988, the research of 45 principal investigators with federally funded grants have been accommodated in these facilities. Currently, the CVC supports the research of 24 UAB faculty representing 11 different departments and divisions within the School of Medicine. The CVC has trained, supervised, and assisted 105 researchers including graduated students, postdoctoral fellows, technicians, and faculty. Currently, there are a total of 64 active CVC users. In addition to R01-type projects, the CVC has supporter the research of major NIH funded program projects and contracts awarded to UAB investigators since 1988, including NCDDG, NCVDG, PEBRA, ACTG, AVEU, NICHD and HIV Genetic Variation projects. Over 300 peer-reviewed scientific publications have results from work performed within the CVC since 1993. Funding is requested to support the basic infrastructure costs of the CVC that remain despite a substantial chargeback system.