EFFECT OF ARGININE SUPPLEMENT IN ADULTS WITH ESSENTIAL HYPERTENSION

L-精氨酸是一种营养丰富的必需氨基酸。 参与了许多生理过程，包括一氧化氮 氧化物(NO)合成。L-精氨酸/NO通路是 心血管自动调节的正常过程和 在原发性高血压患者中可能是缺乏的。 高血压。L-精氨酸补充预防诱导 高血压在大鼠敏感模型中的作用 静脉给药时健康人的低血压。 补充L精氨酸的益处尚不清楚 已在患有高血压的人类身上得到证实。 本研究将探索体内适应机制。 参与精氨酸新陈代谢和动态平衡 全身产生一氧化氮(以NO为单位 排泄)。我们还将相互关联 代谢数据与完整和详尽的临床 评估。10名患者将接受控制饮食 正常的L精氨酸摄入量(56.1mgKg/天)，然后 补充精氨酸(561 mg/kg/天)的等氮 节食。临床结果评估包括每日血量。 压力，以及儿茶酚胺，hANP，AVP， 第一天和第二天的醛固酮、cGMP水平和肾素活性 每个节食期的第七天。在每次节食结束时 期间，将进行8小时稳定同位素标记示踪研究 评估精氨酸、鸟氨酸和尿素 通量以及S通过测量NO的产生 亚硝酸盐/硝酸盐。这一项目将使人们对 补充精氨酸对疾病的潜在益处 涉及L-精氨酸/NO通路，如必不可少 高血压。它还将更完整地定义 体内精氨酸动态平衡的代谢基础 人类成年人。

L-arginine is a nutritionally dispensable amino acid, which is involved in many physiologic processes including nitric oxide (NO) synthesis. The L-arginine/NO pathway is a part of the normal process of cardiovascular autoregulation and it is probably deficient in patients with essential hypertension. L-arginine supplement prevent the induction of hypertension in rat-sensitive models and produce hypotension in healthy humans when given intravenously. The benefit of L-arginine supplementation has not clearly been demonstrated in humans with essential hypertension. This study will explore the in vivo adaptation mechanisms involved in arginine metabolism and homeostasis and in whole body nitric oxide production (measured as NO excretion) in such patients. We will also correlate metabolic data with a complete and exhaustive clinical evaluation. Ten patients will receive a controlled diet with a normal L-arginine intake (56.1 mg/Kg/day) and then an arginine-supplemented (561 mg/Kg/day) isonitrogenous diet. Clinical outcome measures include daily blood pressure, as well as catecholamines, hANP, AVP, aldosterone, cGMP level and renin activity on day one and day seven of each diet period. At the end of each diet period, an 8h stable-isotopic labelled tracer study will be performed to evaluate the arginine, ornithine and urea fluxes as well s the NO production via measurement of nitrite/nitrate. This project will shed new light on the potential benefit of arginine supplement in diseases involving the L-arginine/NO pathway, such as essential hypertension. It will also define more completely the metabolic basis underlying body arginine homeostasis in human adults.