BIOLOGY OF HUMAN AIDS RETROVIRUS

该项目的主要目标是确定 HIV序列变异在引起不同临床症状中的作用 艾滋病的表现。沙门氏菌活体包膜蛋白序列分析 与痴呆症相关的病毒表明，独特的病毒株 可能导致艾滋病毒痴呆症的发生。在……里面 相比之下，其他分析表明，痴呆症与 病毒DNA水平较高。病毒的V3区的影响 巨噬细胞趋向性的包膜基因与NSI和SI 表型被映射到单独的V3氨基酸，它是 发现通常巨噬细胞的嗜性和SI表型是 由不同V3位的氨基酸独立决定。 这一发现为艾滋病毒的发生提供了一个解释 同时表现SI表型和巨噬细胞的菌株 向心性。最近具有传染性的HIV分子克隆 对V3区域及其附近的突变进行了研究 特异性辅受体的利用及其在SCID中的行为 /HuPBL小鼠

The primary goal of this project is to determine the role of variation in HIV sequences in causing the various clinical manifestations seen in AIDS. In vivo env sequence analysis of viruses associated with dementia suggested that unique viral strains may be responsible for the occurrence of HIV dementia. In contrast, other analyses indicated that dementia was not associated with higher levels of viral DNA. The influence of the V3 region of the envelope gene on macrophage tropism and the NSI and SI phenotypes was mapped to individual V3 amino acids, and it was found that usually macrophage tropism and the SI phenotype were independently determined by amino acids at different V3 positions. This finding provides an explanation for the occurrence of HIV strains which exhibit both the SI phenotype and macrophage tropism. More recently infectious HIV molecular clones with mutations in and near the V3 region were studied for their utilization of specific coreceptors and for their behavior in SCID /HuPBL mice