Dissecting Spatial, Regional and Temporal Aspects of the Cancer Epigenome

表观遗传失调通常发生在癌症中，并且不仅可以影响单个基因，而且可以包括大的染色体结构域，导致癌基因和肿瘤抑制基因的表达改变以及基因组不稳定性。我们将研究表观遗传重塑的作用，基因组的空间重组，核结构，染色质循环和复制时机如何影响长距离表观遗传失调，并最终导致癌症的形成和发展。

Epigenetic deregulation occurs commonly in cancer, and can affect not only single genes but can encompass large chromosomal domains, leading to altered expression of oncogenes and tumour suppressor genes, and genomic instability. We will investigate the role of epigenetic remodeling, how spacial reorganisation of the genome, nuclear architecture, chromatin looping and replication timing may affect long range epigenetic deregulation, and ultimately contribute to cancer formation and progression.