CENTRAL AND PERIPHERAL EFFECTS OF BIPERIDEN AND TRIHEXYPHENIDYL

这是一项双盲、安慰剂对照、随机、交叉研究。 确定两种常用药物的中枢和外周效应 15例正常人群的抗胆碱能药物(联苯双酯和苯海索) 志愿者。抗胆碱能药物常用于治疗急性发作 精神分裂症患者中的抗精神病药引起的运动障碍。一个 抗胆碱能药，显示出较高的中枢和 外周抗胆碱药效应在这一组中是有利的。 病人的数量。

This is a double-blind, placebo-controlled, randomized, cross-over study to determine the central and peripheral effects of two commonly used anticholinergic agents (biperiden and trihexyphenidyl) in 15 normal volunteers. Anticholinergic agents are often used to treat acute onset neuroleptic-induced movement disorders in schizophrenic patients. An anticholinergic agent that exhibits a higher ratio of central to peripheral anticholingeric effects would be advantageous in this group of patients.