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EICOSANOID METABOLISM IN HUMAN MONOCYTES & ALVEOLAR MACROPHAGE BY HIV INFECTION

EICOSANOID METABOLISM IN HUMAN MONOCYTES & ALVEOLAR MACROPHAGE BY HIV INFECTION
人类单核细胞中的二十烷酸代谢
批准号：
6274624
负责人：
MICHAEL J. COFFEY
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274624
关键词：
HIV infections alveolar macrophages clinical research diagnostic respiratory lavage eicosanoid metabolism helper T lymphocyte human subject leukocyte count lipoxygenase monocyte prostaglandin endoperoxide synthase

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中文摘要
翻译
这项研究建议研究艾滋病毒增加的机制。 环氧合酶(COX)和降低5-脂氧合酶(5-LO)代谢 1)单核细胞(PBM)2)肺泡巨噬细胞(AM)。具体目标是 目的：1)比较COX和5-LO代谢及COX、5-LO的表达 HIV+患者自体AM和PBM中酶活性的比较 给正常的受试者。这将分两组进行检查，每组不同 严重程度由CD4+T淋巴细胞计数证明；2)确定 来自HIV+的支气管肺泡灌洗液中二十烷类化合物的水平。
英文摘要
This study proposes to examine the mechanisms by which HIV increases cyclooxygenase (COX) and decreases 5-lipoxygenase (5-LO) metabolism in 1) monocytes (PBM) 2) alveolar macrophages (AM). The specific aims are to: 1) compare COX and 5-LO metabolism and expression of COX, and 5-LO enzymes in autologous AM and PBM from healthy HIV+ subjects as compared to normal subjects. This will be examined in 2 groups of varying severity as evidenced by the CD4+ T lymphocyte cell count; 2) determine the level of eicosanoids in bronchoalveolar lavage fluid from the HIV+.
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