REGIONAL CEREBRAL BLOOD FLOW CHANGES DURING ANTICIPATORY ANXIETY

本研究检测了脑局部血流量(RCBF)的变化 焦虑中的受试者。该研究是在以下部门进行的 约翰霍普金斯医学院的精神病学和放射学。它 已经完成，并在神经科学学会上展示 1997年10月25日至30日在新奥尔良举行的年会。一篇文章正在撰写中 在这个时候做准备。以下是对该方法的描述 并进行初步分析。 焦虑发生在承受压力的正常人身上。它还构成了一个 病理性焦虑在缺席时发生的重要因素 压力源。我们研究了焦虑对RCBF的影响。 正常受试者，身心健康，没有 吸毒者(20-37岁，平均23岁，女性4例)。他们经历了4次 连续的正电子发射计算机断层扫描(2次处于中性思维状态，2次处于担忧状态) 015-H20作为示踪剂。在聆听之后，扫描了一些中性的思想 随着一盘2分钟的插花录音带，听完之后就是担忧 录制了一盘2分钟的自录忧虑的磁带(例如金融，疾病在 家庭、工作)。在扫描过程中，受试者继续思考 之前在磁带上听到的主题，直到扫描终止。RCBF 中性思维时与焦虑使用时RCBF的比较 MedX和SPM96。有意义的标准为：Z-Score和GT； 3.11(p&lt；.OOI)和簇中至少25个可配置的2x2x2 mm体素。 在焦虑状态下，R尾状核的rCBF相对增加。 右侧壳核，右侧额下回，右侧顶下小叶，右侧 小脑虫、L小脑后叶和右脑桥。结果是 在担心的同时显示右脑和小脑的激活。 它们与焦虑患者右半球脑电活动增加是一致的 在强迫症患者中可见个体和RCBF增加。

This study examined regional cerebral blood flow (RCBF) changes in subjects during worry. The study was conducted in the departments of Psychiatry and Radiology at The Johns Hopkins School of Medicine. It has been completed and was presented at the Society For Neuroscience annual meeting in New Orleans, October 25-30, 1997. An article is under preparation at this time. Following is a description of the methodology and preliminary analysis. Worrying occurs in normals under stress. It also constitutes an important ingredient of pathological anxiety where it occurs in absence of stressors. We examined the effect of worrying on RCBF in 6 right handed normal subjects, physically and mentally healthy and free of drugs (mean age 23 years, range 20-37, 4 female). They underwent 4 sequential PET scans (2 during neutral thoughts, 2 while worrying) using 015-H20 as tracer. Scans of neutral thoughts followed the listening to a 2-minute tape of flower arrangement, worries followed the listening to a 2 minute tape of self-recorded worries (ex. finance, illness in family, work). During scans, subjects continued to think about the topic previously heard on the tape until termination of the scan. RCBF during neutral thinking was compared with RCBF during worrying using MEDx and SPM96. Criteria for significance were: z-score > 3.11(p<.OOI)and at least 25 configuous 2x2x2mm voxels in the cluster. A relative increase in rCBF during worrying was found in the R caudate, R putamen, R inferior frontal gyrus, R inferior parietal lobule, R cerebellar vermis, L posterior cerebellar lobe and R pons. The results indicate right hemisphere and cerebellar activation while worrying. They are congruent with increased R hemisphere EEG activity in anxious individuals and increased RCBF seen in obsessive compulsive patients.