STIMULATION OF IMMUNITY AGAINST RETROVIRAL ENVELOPE PROTEINS: SAIDS: VACCINE

目的：研究转基因小鼠的抗肿瘤能力， 细菌载体，以刺激粘膜和体液免疫， 猴免疫缺陷病毒的包膜蛋白。 结果A 表达p27的鼠伤寒沙门氏菌重组菌株， 测试它是否会刺激免疫记忆， 促进针对包膜蛋白的抗体应答。 肠道暴露 这种S.也足以增强免疫力， 证明了粘膜和 体液免疫区室 今后的方向 这种细菌载体可以增强免疫记忆， 重要的是要确定这是否 疫苗策略足以促进保护性免疫。 在 此外，重要的是要验证衰减过程 是稳定的，细菌在肠道中不易变异， 环境 关键词SAIDS，粘膜免疫，沙门氏菌 鼠伤寒疫苗

OBJECTIVE: To investigate to ability of a genetically altered bacterial vector to stimulate mucosal and humoral immunity against envelope proteins of simian immunodeficiency virus. RESULTS A recombinant strain of Salmonella typhimurium that expresses p27 was tested to determine if it would stimulate immunological memory and facilitate antibody responses against envelope proteins. Gut exposure to this strain of S.t. was sufficient to augment immunity, also demonstrating the important relationship beween the mucosal and humoral immune compartments. FUTURE DIRECTIONS Having established that this bacterial vector elicits immunological memory against envelope proteins it would be important to determine whether this vaccine strategy is sufficient to promote protective immunity. In addition, it will be important to verify that the attenuation process is stable and that the bacteria is not prone to mutate in the gut environment. KEY WORDS SAIDS, mucosal immunity, Salmonella typhimurium, vaccine