MANGANESE & INFANT FORMULA ON MANGANESE & IRON STATUS OF INFANTS

重要性婴儿配方奶粉含有相当高的含量 锰的浓度比人乳的浓度高。因为很高的身体 锰的负担可能会有毒性作用，研究这一点很重要 从各种配方奶粉中吸收锰的情况如何以及如何 婴儿的锰状况会受到影响。此外，由于锰和 铁的竞争吸收，重要的是评估的效果 高锰摄入量对血液学和铁状态的影响。目标为 饲喂不同水平的奶基和豆基婴儿配方奶粉 锰(35-200ug/L)对初生至6个月龄猴的影响 并研究其对生长、锰吸收和营养的影响。 状态，以及对血液学、铁吸收和状态的影响。 结果高血压病患者对锰、铁的吸收明显低于对照组。 含锰量最高的配方奶粉(大豆配方) 所有其他配方奶粉在6周龄时使用。然而，在3个月大的时候， 两组之间没有差异，这表明身体 锰的负荷不影响锰的存留率。全血 锰反映了锰的摄入量，并在饲喂组中最高 含锰量最高的配方奶粉，而血清铁蛋白 在这一组中排名较低。未来的方向，评估的效果 体内锰水平的增加对各种生理因素都有影响 功能。锰；锰吸收；铁；铁 地位，婴儿营养

Significance Infant formulas contain considerable higher concentrations of manganese than human milk. Since very high body burdens of manganese may have toxic effects, it is important to study how well manganese is absorbed from various types of formula and how manganese status of infants is affected. Further, as manganese and iron compete for absorption, it is important to assess the effect of high manganese intake on hematology and iron status. Objectives To feed milk-based and soy-based infant formulas with different levels of manganese (35-200 ug/L) to infant monkeys from birth to 6 months of age and to study the effects on growth, manganese absorption and status, and the effects on hematology, iron absorption and status. Results Manganese and iron absorption was significantly lower from the formula with the highest level of manganese (soy formula) than from all other formulas at 6 weeks of age. At 3 months of age, however, there was no difference between the groups, suggesting that body burden of manganese does not affect manganese retention. Whole blood manganese reflected manganese intake and was highest in the group fed formula with the highest manganese level, while serum ferritin was lower in this group. Future Directions To evaluate the effect of increased levels of manganese in the body on various physiological functions. KEYWORDS manganese, manganese absorption, iron, iron status, infant nutrition