GRANZYMES OF CYTOTOXIC LYMPHOCYTES
GRANZYMES OF CYTOTOXIC LYMPHOCYTES
批准号:
6280194
负责人:
Dorothy Hudig
金额:
$0.01万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-07-01 至 1999-06-30
中文摘要
利用计算机图形实验室的设施,我们
研究新型颗粒酶的底物结合位点
基于大鼠肥大X射线晶体结构的丝氨酸蛋白酶
细胞糜酶II,另一种丝氨酸蛋白酶。 潜力知识
底物将使它们能够被合成和测试以确定
如果颗粒酶基因产物是活性酶。 这些蛋白酶是
在杀伤细胞的细胞毒性颗粒中,
在杀死病毒感染的细胞和/或
炎症
英文摘要
Using the facilities of the Computer Graphics Laboratory, we are
working on modelling the substrate binding sites of new granzyme
serine proteases, based on the X-ray crystal structure of rat mast
cell chymase II, another serine protease. Knowledge of potential
substrates will allow them to be synthesized and tested to determine
if the granzyme gene products are active enzymes. These proteases are
in cytotoxic granules of killer cells and probably play critical roles
in killing of virally infected cells and/or in signalling for
inflammation.
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Risk of CFS Due to IgG Receptor Genes that Impair ADCC
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批准号:8876331
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项目类别:
-
资助金额:$21.78万
-
财政年份:2015
-
负责人:Dorothy Hudig
-
依托单位:
FACULTY TRAINING CORE
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批准号:7610087
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项目类别:
-
资助金额:$23.7万
-
财政年份:2007
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负责人:Dorothy Hudig
-
依托单位:
FACULTY TRAINING CORE
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批准号:7381458
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项目类别:
-
资助金额:$7.05万
-
财政年份:2006
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负责人:Dorothy Hudig
-
依托单位:
GRANZYMES OF CYTOTOXIC LYMPHOCYTES
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批准号:6119173
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项目类别:
-
资助金额:$0.54万
-
财政年份:1999
-
负责人:Dorothy Hudig
-
依托单位:
CYTOTOXIC LYMPHOCYTE SERINE PROTEASES (GRANZYMES): MODELS OF SPECIFICITIES
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批准号:6250394
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项目类别:
-
资助金额:$0.66万
-
财政年份:1997
-
负责人:Dorothy Hudig
-
依托单位:
LYMPHOCYTE PROTEASE INHIBITORS AS PROBES OF CYTOLYSIS
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批准号:3300736
-
项目类别:
-
资助金额:$19.81万
-
财政年份:1990
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负责人:Dorothy Hudig
-
依托单位:
LYMPHOCYTE PROTEASE INHIBITORS AS PROBES OF CYTOLYSIS
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批准号:3300737
-
项目类别:
-
资助金额:$20.58万
-
财政年份:1990
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负责人:Dorothy Hudig
-
依托单位:
LYMPHOCYTE PROTEASE INHIBITORS AS PROBES OF CYTOLYSIS
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批准号:3300733
-
项目类别:
-
资助金额:$17.63万
-
财政年份:1990
-
负责人:Dorothy Hudig
-
依托单位:
CELL & MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:6164119
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项目类别:
-
资助金额:$0.32万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
Cell and Molecular Cancer Research Training in Nevada
-
批准号:7690976
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项目类别:
-
资助金额:$3.22万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL & MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:2007109
-
项目类别:
-
资助金额:$7.13万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL AND MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:3533554
-
项目类别:
-
资助金额:$4.18万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
Cell and Molecular Cancer Research Training in Nevada
-
批准号:7121659
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项目类别:
-
资助金额:$13.58万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
Cell and Molecular Cancer Research Training in Nevada
-
批准号:7285167
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项目类别:
-
资助金额:$18.93万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL AND MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:2085581
-
项目类别:
-
资助金额:$3.81万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
Cell and Molecular Cancer Research Training in Nevada
-
批准号:7690975
-
项目类别:
-
资助金额:$3.22万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL AND MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:3533552
-
项目类别:
-
资助金额:$4.25万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL AND MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:3533550
-
项目类别:
-
资助金额:$2.79万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL AND MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:2085580
-
项目类别:
-
资助金额:$3.87万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
CELL & MOLECULAR CANCER RESEARCH TRAINING IN NEVADA
-
批准号:2882283
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项目类别:
-
资助金额:$8.94万
-
财政年份:1986
-
负责人:Dorothy Hudig
-
依托单位:
海外基金