课题基金 / 基金详情

PROTEIN TYROSINE PHOSPHATASE: DECIPHERING CATALYTIC MECH & SUBSTRATE SPECIFICITY

PROTEIN TYROSINE PHOSPHATASE: DECIPHERING CATALYTIC MECH & SUBSTRATE SPECIFICITY
蛋白质酪氨酸磷酸酶：破译催化机制
批准号：
6281304
负责人：
MARK A SAPER
金额：
$1.92万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-15 至 1999-08-14
来源：
https://reporter.nih.gov/project-details/6281304
关键词：
biological products biomedical resource proteins radiography structural biology

项目摘要

项目成果

MARK A SAPER的其他基金

相似基金

相关文献

中文摘要
翻译
我们收集了一个优秀的数据集从晶体的双重 特异性磷酸酶VHR与钒酸盐复合。 数据 至少1.6倍 ，并且具有3.5%至1.8%的Rsym .这 结构最近已经解决，并提供了深入了解 磷酸盐水解的过渡态。 一些数据集也 从LAR受体酪氨酸的催化结构域收集 磷酸酶。 从抗DNA Fab的冷冻晶体收集的数据 片段现在被用来改进这种抗体的结构。
英文摘要
We collected an outstanding data set from a crystals of the dual specificity phosphatase VHR complexed with vanadate. The data extended to at least 1.6 , and had an Rsym of 3.5% to 1.8 . This structure recently has been solved and provides insights into the transition state of phosphate hydrolysis. Several data sets were also collected from the catalytic domain of the LAR receptor tyrosine phosphatase. Data collected from frozen crystals of an anti-DNA Fab fragment are now being used to refine the structure of this antibody.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Protein-protein interaction essential for bacterial growth and virulence
Protein-protein interaction essential for bacterial growth and virulence
Crystallization of outer membrane proteins for export of polysaccharide capsule
Crystallization of outer membrane proteins for export of polysaccharide capsule
海外基金