NATIONAL STABLE ISOTOPE RESOURCE AT LOS ALAMOS

我们建议继续运作一个国家稳定同位素 洛斯阿拉莫斯国家实验室（Los Alamos National Laboratory）主要目标 的目的是促进碳同位素的新应用 (12C、13 C 0、氧（12 O、17 O、18 O）、氮（14 N、15 N）、硫（32 S， 33 S、34 S、36 S），以及在较低程度上的硒（77 Se）， 生物化学、生物物理学以及实践中的基本问题 医学科学中的问题。提案的研究部分 建议制定有效的程序，为特定的标签 氨基酸、核酸、酶辅因子和新的起始材料 用于合成。通过将这些材料用于研究， 社区，资源将有助于基础研究， 蛋白质和核酸结构，蛋白质-核酸相互作用， 以及血红素蛋白的结构与功能关系。该资源将 继续开展一系列的核心，服务，协作， 旨在扩大稳定同位素的用途的培训活动， 生物医学研究它将继续为发展中国家作出贡献。 稳定同位素标记化合物的商业化， 将标记的CO和NO转化为有用物质的方法。 成为资源活动重点的特定化合物将 经与资源咨询委员会协商后选定， 将在竞争的基础上提供给外部调查人员。的 后者是资源最重要的服务之一。

We propose to continue the operation of a national stable isotope resource (SIR) at the Los Alamos National Laboratory. The principal goal of the SIR is to promote new applications for the isotopes of carbon (12C, 13C0, oxygen (12O, 17O, 18O), nitrogen (14N, 15N), sulfur (32S, 33S, 34S, 36S), and to a lesser degree selenium (77Se) in solving fundamental problems in biochemistry, biophysics, as well as practical problems in medical science. The research component of the proposal suggests development of efficient procedures for specific labeling of amino acids, nucleic acids, enzyme cofactors, and new starting materials for syntheses. By making these materials available to the research community, the Resource will contribute to fundamental studies of protein and nucleic acid structure, protein-nucleic acid interactions, and structure-function relations in heme proteins. The Resource will continue to carry out a spectrum of core, service, collaborative, and training activities aimed at broadening the uses for stable isotopes in biomedical research. It will continue its contribution to the developing commerce in stable isotopically labeled compounds by devising efficient procedures for converting labeled CO and NO to useful materials. Particular compounds that become the focus of Resource activities will be selected in consultation with the Resource's Advisory Committee and will be provided to external investigators on a competitive basis. The latter is one of the most important services of the Resource.