EFFECTS OF SEX STEROIDS ON GROWTH HORMONE CONCENTRATIONS

我们将测试目前用于治疗的疗法的假设 儿童白血病和淋巴瘤(全身/鞘内化疗和 小剂量，1800cGy.头部照射)会对神经调节造成损害 大脑中负责性激素调节的增加的中枢 生长激素的产生。因此，这些个体产生了 青春期前的生长激素水平正常，但不能证明 性激素(两者)引起的生长激素浓度的预期增加 内源和外源)。

We will test the hypothesis that the therapies currently employed to treat childhood leukemias and lymphomas (systemic/intrathecal chemotherapy and lwo-dose, 1800cGy, cranial radiation) cause damage to the neuroregulatory centers int he brain responsible for the sex steroid mediated increase in growth hormone production. As a consequence, these individuals produce normal amounts of GH in the prepubertal years but fail to demonstrate the expected increase in GH concentration in response to sex steroids (both endogenous and exogenous).