INDUCED ABORTION AND BREAST CANCER RISK

(改编自申请人摘要)：人工流产已被 与乳腺癌风险增加有关，但只是一小部分 许多进行得很好的研究已经报道了这种关系。一个 对这些研究中报告的结果的主要挑战涉及 关于人工流产的自我报告信息可能不准确： 乳腺癌患者可能比没有乳腺癌的女性更愿意 威胁生命的疾病报告他们的堕胎史，结果 虚假的、积极的发现。我们提出了一个基于人口的案例-- 对照研究以检验两者之间的关系。提高…的精确度 关于人工流产的信息，这项研究将在 中国，在上海，人工流产不被污名化，在哪里 计划生育记录记录了生育史。所有上了年纪的女性 54岁及以下，1997年新诊断为乳腺癌 到1999年年中，并居住在上海，将通过 以人口为基础的上海市癌症登记中心。相同年龄的人- 匹配的对照将从人群中随机选择 地理区域。约1,470例病例和1,470例对照将 采访以确定所有这些事件的数量、时间和结果 怀孕；其他生殖、月经和避孕措施 特征；乳腺癌家族史；以及其他危险因素 治疗乳腺癌。此外，我们还将抽象出生殖 计生委对每一位参与者的记录。 它们包含每次怀孕的详细病史，将被用来 提高人工流产信息的准确性。医疗 将请求记录以获取有关良性疾病历史的信息 乳房疾病和乳腺癌筛查服务的使用。这个 人工流产和自然流产与乳腺癌风险的关系 将根据流产时的年龄、产次和分娩时间进行检查 流产(首次足月妊娠前后、间隔至 下一次足月妊娠，胎龄。)是否应该与之建立关系？ 如果人工流产被发现，就有可能为那些 考虑堕胎更好地了解堕胎的可能风险 与年龄、产次和手术时机有关的手术。

(Adapted from the Applicant's Abstract): Induced abortion has been associated with an increased risk of breast cancer, but only a small number of well-conducted studies have reported on the relationship. A key challenge to the findings reported in those studies concerns the possible inaccuracy of self-reported information on induced abortion: Breast cancer cases may have been more willing than women without a life-threatening illness to report their history of abortion, resulting in spurious, positive findings. We propose a population-based case- control study to examine the relationship. To increase the accuracy of information on induced abortion, the study will be conducted in Shanghai, China, where induced abortion is not stigmatized and where family planning records document reproductive history. All women aged 54 years and younger, newly diagnosed with breast cancer during 1997 through mid-1999 and resident in Shanghai, will be identified through the population-based Shanghai Cancer Registry. The same number of age- matched controls will be randomly selected from the population of the geographic area. Approximately 1,470 cases and 1,470 controls will be interviewed to ascertain the number, timing, and outcome of all pregnancies; other reproductive, menstrual, and contraceptive characteristics; family history of breast cancer; and other risk factors for breast cancer. In addition, we will abstract the reproductive records dept for each participant by the Family Planning Committee. They contain a detailed history of each pregnancy and will be used to enhance the accuracy of the information on induced abortion. Medical records will be requested to obtain information on a history of benign breast disease and use of breast-cancer screening services. The association of induced and spontaneous abortion with breast cancer risk will be examined in relation to age at abortion, parity, and timing of the abortion (before and after first full-term pregnancy, interval to next full-term pregnancy, gestational age.) Should a relationship with induced abortion be found, it will be possible to provide women who are contemplating abortion better information on the possible risks of the procedure in relation to age, parity, and timing of the procedure.