IDENTIFICATION AND CONTROL OF CANCER RISK

描述：(改编自申请人摘要)。这一行动的主要目标是 这项研究是为了检验这样一种假设，即沥青中过量的癌症风险 劳动者是因其职业暴露而产生的，并对其进行评估 暴露在沥青中会有致癌风险。除了调查 观察到的癌症风险标记物可归因于 职业性沥青暴露、吸入的相对重要性和 将对皮肤暴露途径进行评估，以提供 以降低这种风险的干预策略。已经有大约20个 屋顶工人和高速公路人群癌症风险的流行病学研究 维修工人，以及几个地点癌症的超额风险(肺， 胃病、非黑色素瘤皮肤和白血病)在屋顶工人中有报道 持续显示出比公路养护工人更大的风险。 职业性暴露于多环芳烃已被提出用来解释超额风险 在这两组中，但没有进行详细的暴露评估，以 支持这个协会。 计划进行一项前瞻性研究，包括全面的 暴露评估，以检查暴露于多环芳烃之间的联系 以及以多环芳烃-DNA加合物的形式表示致癌物质损害的生物标志物。 这项拟议的研究将：1)招募至少100名工人 用于屋顶和高速公路铺装，并有一定范围的沥青裸露；2) 使用以下工具对其职业性多环芳烃暴露进行全面评估 他们把工作任务作为曝光的中心组织原则 评估；3)开发基于任务的模型以估计多环芳烃暴露 在为期一年的前瞻性研究中；4)测量PAH-DNA的变化 这些工人在工作年度的单个核细胞中的加合物水平； 5)用线性回归方法评价皮肤和呼吸道的贡献 多环芳烃暴露、吸烟、饮食等因素对多环芳烃DNA水平的影响 加合物；6)制定干预策略以降低癌症风险 由职业性多环芳烃暴露造成的，使用 吸入和皮肤暴露的相对重要性以及 针对特定任务的风险暴露衡量标准。

DESCRIPTION: (Adapted from Applicant's Abstract). The major goal of this study is to test the hypothesis that the excess cancer risk among asphalt workers is a result of their occupational exposure, and to assess the role of asphalt exposure as a cancer risk. In addition to investigating the degree to which the observed marker for cancer risk is attributable to occupational asphalt exposure, the relative importance of inhalation and dermal routes of exposure will be assessed to provide the basis for an intervention strategy to reduce that risk. There have been approximately 20 epidemiologic studies done on cancer risk among roofers and highway maintenance workers, and excess risk of cancer for several sites (lung, stomach, non-melanoma skin, and leukemias) have been reported with roofers consistently demonstrating greater risks than highway maintenance workers. Occupational exposure to PAHs has been proposed to explain the excess risk in these two groups, but no detailed exposure assessments have been done to support this association. The plan is to conduct a prospective study, including comprehensive assessment of exposure, to examine the association between exposure to PAH and a biological marker of carcinogen damage in the form of PAH-DNA adducts. The proposed research will: 1) recruit a population of at least 100 workers employed in roofing and highway paving with a range of asphalt exposures; 2) conduct a comprehensive evaluation of their occupational PAH exposure using their work task as the central organizing principle of the exposure assessment; 3) develop a task-based model for estimating the PAH exposures during the one-year prospective study; 4) measure the change in PAH-DNA adduct levels in mononuclear cells of these workers over the working year; 5) evaluate by linear regression the contribution of dermal and respiratory PAH exposure, smoking, diet and other factors to the level of PAH-DNA adducts; 6) develop an intervention strategy to reduce the risk of cancer resulting from occupational PAH exposures, using the information on the relative significance of inhalation and dermal exposure and the task-specific measures of exposure.