FACTORS AFFECTING CALORIC REGULATION IN HUMAN FEEDING

描述：这是一份写得很好的申请，来自一位调查员， 长期支持。 这些研究使用人类受试者， 三个实验，四个目标。 第一个目标是评估 假设高脂肪饮食的高能量摄入是由于能量 这些食物的密度，而不是具体涉及到其他属性 脂肪本身。 在第二个具体目标中，所评估的假设是， 食物的重量通过预吸收机制起作用， 养分含量通过吸收后机制起作用。 第三 具体目标的目的是测试假设，肥胖的人有一个 对食物的能量和脂肪含量的感知和反应能力受损 在短期和长期内。 第四个具体目标是测试 低能量强度的食物是否真的抑制了初始的 饥饿和延长饱腹感时，他们匹配高密度的食物 按重量计算。 测试这些假设的实验涉及两个 短期喂养研究操纵预负荷，但显着 涉及对同一个主题进行多次开庭。 第三 实验是对具有相似能量密度的饮食进行长期比较， 不同的脂肪含量，然后做相反的实验， 能量密度，同时固定脂肪含量。 实验仔细地改变了脂肪 内容，同时保持能量含量恒定，反之亦然， 保持恒定的适口性。

DESCRIPTION: This is a well-written application from an investigator with a long period of support. These investigations use human subjects and involve three experiments addressing four aims. The first aim is to assess the hypothesis that high energy intakes on high fat diets are due to the energy density of those foods rather than specifically relating to other properties of fat itself. In the second specific aim the hypothesis evaluated is that the weight of food acts through preabsorptive mechanisms while energy and nutrient content act through postabsorptive mechanisms. In the third specific aim the intent is to test the hypothesis that obese humans have an impaired ability to sense and respond to energy and fat content of foods within the short and long term periods. The fourth specific aim is to test whether it is true that foods of low energy intensity suppress initial hunger and prolong satiety more when they are matched to high density foods on a weight basis. The experiments testing these hypotheses involve two sets of short term feeding studies manipulating preloads, but significantly involving multiple sittings for the same individual subject. The third experiment is a long term comparison of diets of similar energy density but differing in fat content and then doing the reverse experiment of changing energy density while fixing fat content. The experiments carefully vary fat content while keeping the energy content constant or vice versa, all while maintaining constant palatability.