CRAVING AND CUE REACTIVITY IN ADOLESCENT ALCOHOLICS

申请人摘要：酗酒和酗酒是一个 在青少年中越来越普遍。虽然继续努力 防止青少年饮酒，从而防止滥用 和/或依赖，还需要提供有效的治疗方法 已经对酒精产生依赖的青少年。 在过去的两年里，对成年酗酒者的治疗取得了实质性的进展。 几十年例如，有特定的心理疗法（例如，线索暴露 治疗）和药物治疗（例如，阿片拮抗剂），可减少 并帮助成年酗酒者抵制饮酒的冲动。 这些治疗方法尚未广泛用于青少年酗酒者，部分原因是 因为不知道青少年是否像成年人一样渴望酒精。的 目前的研究建议通过首先开发酒精来解决这一空白 评估青少年的渴望和线索诱导反应所需的线索。的 第一阶段的目标是收集有关视觉线索的信息， 青少年酗酒者的饮酒冲动这些线索将被拍照， 制作成35毫米的幻灯片。载玻片将在第2阶段进行检测， 青少年酗酒者将报告哪些幻灯片的子集产生了 最大的欲望就是喝酒。在第三阶段，酗酒青少年和匹配的对照组 将比较他们对这些幻灯片的反应。是 假设酒精组会表现出更大的线索诱导反应， 并且比对照组报告更大的主观渴望。 研究结果将指导未来了解 青少年酗酒，青少年是否渴望，如果是，可能的 治疗这个人群。

APPLICANT'S ABSTRACT: Alcohol abuse and alcoholism are problems that are becoming increasingly more prevalent in adolescents. While continued efforts are being made to prevent alcohol use among youth, thereby preventing abuse and/or dependence, there is also the need to provide effective treatments for adolescents who have already become dependent on alcohol. Treatment for adult alcoholics has made substantial progress in the past two decades. For example, there are specific psychotherapies (e.g., cue-exposure therapy) and pharmacotherapies (e.g., opiate antagonists) that may reduce craving and help the adult alcoholic resist urges to drink. These treatments have not been widely used in adolescent alcoholics, in part because it is not known whether adolescents crave alcohol as adults do. The present study is proposed to address this void by first developing the alcohol cues needed to assess craving and cue-induced reactivity in adolescents. The goal of Phase 1 is to gather information about visual cues that may elicit urges to drink in adolescent alcoholics. These cues will be photographed and developed into 35 mm slides. The slides will be tested in Phase 2, and adolescent alcoholics will report which subset of the slides produced the greatest urge to drink. In Phase 3, alcoholic adolescents and matched controls will be compared on how they respond to these photographic slides. It is hypothesized that the alcoholic group will show greater cue-induced reactivity and report greater subjective craving than will the control group. The results of the study will guide future efforts to understand the nature of adolescent alcoholism, whether adolescents crave, and if so, possible treatments for this population.