Malt Liquor Preference/Pharmacokinetics in AfriAmerican

描述(由申请人提供)： 酗酒在非洲造成社会、环境和医疗后果 给美国人带来了毁灭性的经济后果。该计划的总体目标 建议的研究是确定高酒精与 内容物麦芽饮料及其对提高 研究人群中城市非裔美国人的消费模式 以前在大多数研究活动中的代表性不足。的重要意义。 麦芽酒是导致酒精中毒或酗酒的特定因素 在任何人口中都没有被研究到任何重要的程度。这项研究 设计解决了三个重要的问题：麦芽的消费是如何 酒与开始饮酒、心理-社会表型和 出现酒精问题，包括酗酒和依赖。是 麦芽酒的消费模式与年龄有关，以及 社会经济地位？酒精的药代动力学有差异吗？ 口服麦芽酒后的吸收和/或消除？ 提出了两个具体目标：(1)采用以人群为基础的研究设计， 确定与酒精饮料偏好相关的特定用户特征 包括使用频率和消费水平、经济、心理社会、 行为和环境因素以及ADH基因在300名队列中的分布 城市非裔美国男性，特别强调 麦芽酒精饮料对这些因素的偏好。的贡献 发展中的广告、烟草使用和精神等因素 还将探索麦芽酒的偏好。从这些数据中，一名临床医生 这些饮料的活跃、依赖和非依赖使用者的表型 (2)使用交叉研究设计，60名健康 非酒精依赖型非裔美国男性，年龄21-25岁，将被招募到 测定和量化酒精药代动力学中的生物差异 在急性口服普通啤酒和/或麦芽酒后 不同的酒精浓度，使用口服酒精挑战模型 包含旨在减少受试者变异性的内部控制。这个 这项拟议研究的理由因提供了 众多发展良好的学科招聘网站，现有的科学和 行政团队应对招聘大型种族员工的挑战 同类队列，大量现有培训/经验 管理类似的测试仪器和临床程序， 美国国立卫生研究院资助的能够支持口服酒精的GCRC的可用性 挑战研究以及管理和科学基础设施 NIAAA合作酒精研究中心。从这些研究中，我们的 对影响麦芽偏好的关键因素的认识 将白酒进行鉴定并推定其生物学基础 酒精药代动力学的差异将被描述。

DESCRIPTION (provided by applicant): Alcoholism produces social, environmental and medical outcomes in African Americans with devastating economic consequences. The overall goal of the proposed research is to determine the relationship between high alcohol content malt Beverages and the contribution such beverages make to increased consumption patterns among urban African Americans, a study population previously under represented in most research activities. The significance of malt liquor as a contributing specific factor in alcoholism or alcohol abuse has not been studied to any significant degree in any population. The study design addresses three important questions: How is the consumption of malt liquor associated with the onset of drinking, psycho-social phenotypes and the development of alcohol problems, including alcohol abuse and dependence. Are there differences in malt liquor consumption patterns related to age, and socioeconomic status? Are there pharmacokinetic differences in alcohol absorption and/or elimination following the oral ingestion of malt liquors? Two Specific Aims are proposed: (1) Using a population-based study design, identify specific user characteristics related to alcohol beverage preferences including use frequency and consumption levels, economic, psychosocial, behavioral and environmental factors, and ADH genotype among a cohort of 300 urban African American males with specific emphasis on the relationship of malt alcoholic beverage preference to these factors. The contribution of factors such as advertising, tobacco use and spirituality in the development of malt liquor preference will also be explored. From these data, a clinical phenotype of an active dependent and non-dependent user of these beverages will be identified, and (2) Using a cross-over study design, sixty healthy non-alcohol dependent African American males, age 21-25 will be recruited to determine and quantify biological differences in alcohol pharmacokinetics following the acute oral consumption of regular beer and/or malt liquors of varying alcohol concentrations, using an oral alcohol challenge model containing internal controls designed to reduce subject variability. The rationale for the proposed study is strengthened by the availability of numerous well developed subject recruitment sites, an existing scientific and administrative team to meet the challenge of recruiting a large ethnically homogenous cohort, substantial existing training/experience in the administration of similar test instruments and clinical procedures, availability of a NIH funded GCRC with the ability to support the oral alcohol challenge studies, and the administrative and scientific infrastructure of a NIAAA Collaborative Alcohol Research Center. From these studies, our understanding of the critical factors influencing the preference for malt liquor will be identified and the biological basis for the presumed differences in alcohol pharmacokinetics will be described.