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NHLBI Research Center at Howard University

霍华德大学 NHLBI 研究中心

基本信息

批准号：
8083216
负责人：
ROBERT E. TAYLOR
金额：
$ 20.72万
依托单位：
HOWARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8083216
关键词：
Activities of Daily Living Adolescent Affect African African American Anemia Award Behavioral Research Biomedical Research Blood CDK2 gene Cells Chelating Agents Child Clinical Clinical Research Complement DNA-Directed RNA Polymerase Direct Costs Disease Doctor of Philosophy Echocardiography Evaluation Research Exposure to Facilities and Administrative Costs Faculty Functional disorder Funding Genetic Transcription Goals Grant Growth HIV HIV-1 Heart Hemoglobinopathies Hemolysis Hypoxia Hypoxia Inducible Factor Individual Institution Iron Iron Overload Laboratories Lead Leadership Left Lung Medical Students Mentors Minority Minority-Serving Institution Molecular Mutation National Heart, Lung, and Blood Institute Oxygen Oxygen measurement, partial pressure, arterial Peer Review Polycythemia Population Postdoctoral Fellow Publications Pulmonary artery structure Recruitment Activity Research Research Personnel Research Project Grants Research Scientist Award Resistance Resources Scientific Advances and Accomplishments Scientist Sickle Cell Anemia Sleep Students Training Universities Up-Regulation VHL mutation Ventricular follow-up graduate student health disparity hepcidin high school iron metabolism member metal transporting protein 1 pressure programs success

项目摘要

The purpose of this proposal to establish an NHLBI Research Center at Howard University that will augment and Strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung and blood, and sleep diseases and disorders. The focus of the Center will be hemoglobinopathies, iron metabolism and oxygen-sensing, and It will build on and synergize with our existing NHLBI Research Scientist Program. From 1999 to 2010, the NHLBI Research Scientist Award at Howard University has facilitated the organization of a new research program that has contributed to the acquisition of 34 additional grants with total direct costs of over $29,000,000 and total Indirect costs of over $9,000,000. The program has been instrumental in bringing 11 new research faculty to Howard University. It has also provided research opportunities for 22 undergraduate students, 14 medical students, 7 masters level graduate students, 8 PhD candidates, 10 post-doctoral candidates, 19 residents and fellows, and 22 existing faculty members. Progress has been made in a variety of diseases that disproportionately affect minority populations, including severe malarial anemia, non-HFE iron overload, the influence of underlying hematologic conditions on HIV disease, and the pulmonary complications of sickle cell disease. The Award has resulted in 150 peer-reviewed publications. Building on this success, we now propose to establish an NHLBI Research Center at Howard University. Aim 1. Establish an External Advisory Board of six external scientists who will advise the proposed NHLBI Research Center at Howard University leadership and provide an evaluation of the research program. Aim 2. Recruit an additional established scientist who can complement and build upon our existing research program in hemglobinopathies, iron metabolism and oxygen sensing. Aim 3. Expand and enhance the research advances made by the existing NHLBI Research Scientist Program at Howard University in clinical and molecular aspects of sickle cell disease, iron metabolism and oxygen sensing in African-Americans and other populations.

该提案的目的是在霍华德大学建立 NHLBI 研究中心，以增强和加强与心脏、肺和血液以及睡眠疾病和障碍相关的生物医学和行为研究的研究能力和资源。该中心的重点将是血红蛋白病、铁代谢和氧传感，它将建立在我们现有的 NHLBI 研究科学家计划的基础上并与之产生协同作用。从 1999 年到 2010 年，霍华德大学的 NHLBI 研究科学家奖促进了一项新研究计划的组织，该计划已促成获得 34 项额外拨款，直接成本总额超过 29,000,000 美元，间接成本总额超过 9,000,000 美元。该计划为霍华德大学引进了 11 名新的研究人员。它还为22名本科生、14名医学生、7名硕士研究生、8名博士生、10名博士后候选人、19名住院医师和研究员以及22名现有教职人员提供了研究机会。在对少数群体影响尤为严重的多种疾病方面已经取得了进展，包括严重疟疾贫血、非 HFE 铁超载、潜在血液状况对艾滋病毒疾病的影响以及镰状细胞病的肺部并发症。该奖项已产生 150 份经过同行评审的出版物。在此成功的基础上，我们现在提议在霍华德大学建立 NHLBI 研究中心。目标 1. 建立一个由六名外部科学家组成的外部顾问委员会，他们将为拟议的霍华德大学 NHLBI 研究中心领导层提供建议，并对研究计划进行评估。目标 2. 招募一名额外的知名科学家，他可以补充和发展我们在血红蛋白病、铁代谢和氧传感方面的现有研究项目。目标 3. 扩大和加强霍华德大学现有 NHLBI 研究科学家计划在非裔美国人和其他人群的镰状细胞病、铁代谢和氧传感的临床和分子方面取得的研究进展。