NHLBI Research Center at Howard University

霍华德大学 NHLBI 研究中心

基本信息

批准号：
8289429
负责人：
ROBERT E. TAYLOR
金额：
$ 20.69万
依托单位：
HOWARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8289429
关键词：
Activities of Daily Living Adolescent Affect African African American Anemia Award Behavioral Research Biomedical Research Blood CDK2 gene Cells Chelating Agents Child Clinical Clinical Research Complement DNA-Directed RNA Polymerase Direct Costs Disease Doctor of Philosophy Echocardiography Evaluation Research Exposure to Facilities and Administrative Costs Faculty Functional disorder Funding Genetic Transcription Goals Grant Growth HIV HIV-1 Heart Hemoglobinopathies Hemolysis Hypoxia Hypoxia Inducible Factor Individual Institution Iron Iron Overload Laboratories Lead Leadership Left Lung Medical Students Mentors Minority Minority-Serving Institution Molecular Mutation National Heart, Lung, and Blood Institute Oxygen Oxygen measurement, partial pressure, arterial Peer Review Polycythemia Population Postdoctoral Fellow Publications Pulmonary artery structure Recruitment Activity Research Research Personnel Research Project Grants Research Scientist Award Resistance Resources Scientific Advances and Accomplishments Scientist Sickle Cell Anemia Sleep Students Training Universities Up-Regulation VHL mutation Ventricular follow-up graduate student health disparity hepcidin high school iron metabolism member metal transporting protein 1 pressure programs success undergraduate student

项目摘要

The purpose of this proposal to establish an NHLBI Research Center at Howard University that will augment and Strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung and blood, and sleep diseases and disorders. The focus of the Center will be hemoglobinopathies, iron metabolism and oxygen-sensing, and It will build on and synergize with our existing NHLBI Research Scientist Program. From 1999 to 2010, the NHLBI Research Scientist Award at Howard University has facilitated the organization of a new research program that has contributed to the acquisition of 34 additional grants with total direct costs of over $29,000,000 and total Indirect costs of over $9,000,000. The program has been instrumental in bringing 11 new research faculty to Howard University. It has also provided research opportunities for 22 undergraduate students, 14 medical students, 7 masters level graduate students, 8 PhD candidates, 10 post-doctoral candidates, 19 residents and fellows, and 22 existing faculty members. Progress has been made in a variety of diseases that disproportionately affect minority populations, including severe malarial anemia, non-HFE iron overload, the influence of underlying hematologic conditions on HIV disease, and the pulmonary complications of sickle cell disease. The Award has resulted in 150 peer-reviewed publications. Building on this success, we now propose to establish an NHLBI Research Center at Howard University. Aim 1. Establish an External Advisory Board of six external scientists who will advise the proposed NHLBI Research Center at Howard University leadership and provide an evaluation of the research program. Aim 2. Recruit an additional established scientist who can complement and build upon our existing research program in hemglobinopathies, iron metabolism and oxygen sensing. Aim 3. Expand and enhance the research advances made by the existing NHLBI Research Scientist Program at Howard University in clinical and molecular aspects of sickle cell disease, iron metabolism and oxygen sensing in African-Americans and other populations.

该提案的目的是在霍华德大学建立NHLBI研究中心，该中心将增强并增强与心脏，肺和血液以及睡眠疾病和疾病有关的生物医学和行为研究的研究能力和资源。该中心的重点将是血红蛋白病，铁代谢和氧气感应，它将与我们现有的NHLBI研究科学家计划建立并协同作用。从1999年到2010年，霍华德大学的NHLBI研究科学家奖促进了一项新的研究计划的组织，该计划有助于收购34个额外的赠款，总直接成本超过29,000,000美元，间接成本超过9,000,000美元。该计划在将11位新的研究学院带到霍华德大学方面发挥了作用。它还为22名本科生，14名医学生，7名硕士研究生，8名博士学位候选人，10名博士后候选人，19名居民和研究员以及22名现有教职员工提供了研究机会。在多种疾病中已经取得了进展，这些疾病对少数群体的影响不成比例，包括严重的疟疾贫血，非HFE铁超负荷，潜在的血液学疾病对HIV疾病的影响以及镰状细胞病的肺部并发症。该奖项导致了150个同行评审的出版物。在这一成功的基础上，我们现在建议在霍华德大学建立NHLBI研究中心。目标1。建立一个由六位外部科学家组成的外部顾问委员会，他们将为霍华德大学领导层的拟议的NHLBI研究中心提供建议，并对研究计划进行评估。目标2。招募一位知名的科学家，他们可以在我们现有的血红蛋白病，铁代谢和氧气传感方面进行补充和建立。 AIM 3。扩展和增强霍华德大学现有NHLBI研究科学家计划在镰状细胞疾病的临床和分子方面，非裔美国人和其他人群中的临床和分子方面的研究进步。