NHLBI Research Center at Howard University

霍华德大学 NHLBI 研究中心

• 批准号: 8289429
• 负责人: ROBERT E. TAYLOR
• 金额: $ 20.69万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8289429
• 关键词: Activities of Daily Living; Adolescent; Affect; African; African American; Anemia; Award; Behavioral Research; Biomedical Research; Blood; CDK2 gene; Cells; Chelating Agents; Child; Clinical; Clinical Research; Complement; DNA-Directed RNA Polymerase; Direct Costs; Disease; Doctor of Philosophy; Echocardiography; Evaluation Research; Exposure to; Facilities and Administrative Costs; Faculty; Functional disorder; Funding; Genetic Transcription; Goals; Grant; Growth; HIV; HIV-1; Heart; Hemoglobinopathies; Hemolysis; Hypoxia; Hypoxia Inducible Factor; Individual; Institution; Iron; Iron Overload; Laboratories; Lead; Leadership; Left; Lung; Medical Students; Mentors; Minority; Minority-Serving Institution; Molecular; Mutation; National Heart, Lung, and Blood Institute; Oxygen; Oxygen measurement, partial pressure, arterial; Peer Review; Polycythemia; Population; Postdoctoral Fellow; Publications; Pulmonary artery structure; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Scientist Award; Resistance; Resources; Scientific Advances and Accomplishments; Scientist; Sickle Cell Anemia; Sleep; Students; Training; Universities; Up-Regulation; VHL mutation; Ventricular; follow-up; graduate student; health disparity; hepcidin; high school; iron metabolism; member; metal transporting protein 1; pressure; programs; success; undergraduate student

The purpose of this proposal to establish an NHLBI Research Center at Howard University that will augment and Strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung and blood, and sleep diseases and disorders. The focus of the Center will be hemoglobinopathies, iron metabolism and oxygen-sensing, and It will build on and synergize with our existing NHLBI Research Scientist Program. From 1999 to 2010, the NHLBI Research Scientist Award at Howard University has facilitated the organization of a new research program that has contributed to the acquisition of 34 additional grants with total direct costs of over $29,000,000 and total Indirect costs of over $9,000,000. The program has been instrumental in bringing 11 new research faculty to Howard University. It has also provided research opportunities for 22 undergraduate students, 14 medical students, 7 masters level graduate students, 8 PhD candidates, 10 post-doctoral candidates, 19 residents and fellows, and 22 existing faculty members. Progress has been made in a variety of diseases that disproportionately affect minority populations, including severe malarial anemia, non-HFE iron overload, the influence of underlying hematologic conditions on HIV disease, and the pulmonary complications of sickle cell disease. The Award has resulted in 150 peer-reviewed publications. Building on this success, we now propose to establish an NHLBI Research Center at Howard University. Aim 1. Establish an External Advisory Board of six external scientists who will advise the proposed NHLBI Research Center at Howard University leadership and provide an evaluation of the research program. Aim 2. Recruit an additional established scientist who can complement and build upon our existing research program in hemglobinopathies, iron metabolism and oxygen sensing. Aim 3. Expand and enhance the research advances made by the existing NHLBI Research Scientist Program at Howard University in clinical and molecular aspects of sickle cell disease, iron metabolism and oxygen sensing in African-Americans and other populations.

本提案的目的是在霍华德大学建立一个NHLBI研究中心，以增强和加强与心脏、肺和血液以及睡眠疾病和障碍相关的生物医学和行为研究的研究能力和资源。该中心的重点将是血红蛋白病，铁代谢和氧传感，它将建立和协同与我们现有的NHLBI研究科学家计划。从1999年到2010年，霍华德大学的NHLBI研究科学家奖促进了一项新研究计划的组织，该计划为获得34项额外赠款做出了贡献，直接费用总额超过2900万美元，间接费用总额超过900万美元。该计划为霍华德大学带来了11名新的研究人员。它还为22名本科生，14名医科学生，7名硕士研究生，8名博士候选人，10名博士后候选人，19名居民和研究员以及22名现有教职员工提供了研究机会。在不成比例地影响少数群体的各种疾病方面取得了进展，包括严重疟疾性贫血、非HFE铁超载、基础血液学状况对艾滋病毒疾病的影响以及镰状细胞病的肺部并发症。该奖项已产生150份同行评审出版物。在这一成功的基础上，我们现在建议在霍华德大学建立一个NHLBI研究中心。 目标1.建立一个由六名外部科学家组成的外部咨询委员会，他们将为霍华德大学拟议的NHLBI研究中心提供建议，并对研究计划进行评估。 目标2.招募一名能够补充和建立我们在血红蛋白病，铁代谢和氧传感方面现有研究计划的科学家。 目标3.扩大和加强现有的NHLBI研究科学家计划在霍华德大学在镰状细胞病，铁代谢和氧传感在非洲裔美国人和其他人群的临床和分子方面取得的研究进展。