EPIDEMIOLOGY OF TYPHOID FEVER IN INDIA

伤寒被认为是印度的一个主要问题，但其真实发病率尚不确定。为了准备伤寒疫苗的未来田间试验，本研究在印度新德里建立了一个城市田间试验点，以监测一组受试者的伤寒发病率。德里的遗址包括约19，000人。在12个月的监测期间，伤寒发病率为每1 000人9.9例。对所有伤寒病例进行长达3个月的随访，以确定与伤寒相关的残疾，并在这些队列中进行病例对照研究，以评估与伤寒风险相关的食物、水源和卫生习惯，以及H. pylori合并感染对这种危险性的影响。项目将于1999年终止。- 伤寒沙门氏菌，伤寒，印度，监测，发病率-人类受试者

Typhoid fever is perceived to be a major problem in India, but its true incidence is uncertain. In preparation for future field trials of typhoid vaccines, this research established an urban field site in New Delhi, India, to monitor typhoid incidence in a cohort of subjects. The site in Delhi comprised a population of about 19,000 persons. During 12 months of surveillance, the incidence of typhoid fever was 9.9 cases per 1,000. All cases of typhoid were followed for up to 3 months to determine typhoid-related disability, and case-control studies were nested within these cohorts to assess foods, water sources, and hygienic practices associated with typhoid risk, as well as the role of H. pylori coinfection in influencing this risk.Project will be terminated in 1999. - Salmonella typhi, typhoid fever, India, surveillance, incidence - Human Subjects