HEALTH EFFECTS OF PESTICIDES

工作总结：目前我正在做的项目有两个是关于农药的。一项是工人健康研究，研究长期接触农药的农场工人的神经功能。在另一篇文章中，我正在分析农业健康研究中关于农场妇女生殖健康的数据。在工人健康研究中，我牵头进行了暴露评估和有机磷农药遗传易感性与神经功能关系的分析。利用收集的DNA拭子，我们将分析两种多态性（PON1和PON2）之间的关系。这些对氧磷酶多态性被认为在心脏病的氧化应激介导和有机磷农药解毒中发挥作用。在农业健康研究中，我正在分析农药和其他农场暴露与农场妇女月经周期异常、胎儿流产和早产之间关系的数据。我还致力于通过收集职业农药卫生信息，开发改进农药暴露问卷评估的方法。这个项目一直被清理数据集的困难所困扰。由于调查问卷数量庞大（超过7万份），我们花了几年时间制定数据清理程序，并试图将数据集清理干净。在接下来的几周内，我们应该有一个干净的数据集，并将能够开始繁殖分析。从工人健康研究中提取的DNA正在提取过程中，多态性正在分析中。几个月后我们就能得到这些数据。-农药，农民，农场工人，对氧磷酶，环境雌激素，神经系统影响，月经周期，自然流产，早产-人类受试者：访谈，问卷调查或仅调查

Summary of Work: There are two projects I am working on concerning pesticides. One is the Workers Health study, a study of neurologic function among farmworkers chronically exposed to pesticides. In the other I am analyzing data on the reproductive health of women living on farms in the Agricultural health study.For the workers health study, I am taking the lead on analyses on exposure assessment and on the relationship between genetic susceptibility to organophosphate pesticides and neurologic function. Using DNA collected from cheek swabs we will analyze the relationship between two polymorphisms (PON1 and PON2). These paraoxonase polymorphisms are believed to play a role in mediating oxidative stress in heart disease and in detoxifying organophosphate pesticides.For the Agricultural health study, I am analyzing data on the relationship between pesticide and other farm exposures and menstrual cycle abnormalities, fetal loss and preterm births among women living on farms. I am also working on developing methods to improve questionnaire assessment of pesticide exposure by collecting information on occupational pesticide hygiene. This project has been plagued by difficulties with difficulties cleaning the datasets. Because they are so large (over 70,000) questionnaires, we spent the last several years working out data cleaning procedures and trying to get the datasets clean. Within the next few weeks, we should have a clean dataset and will be able to begin the reproductive analyses. The DNA from the workers health study is in the process of being extracted and the polymorphisms are being analyzed. We should have this data in the next few months. - pesticides, farmers, farmworkers, paraoxonase, environmental estrogens, neurologic effects, menstrual cycle, spontaneous abortion, preterm - Human Subjects: Interview, Questionaires, or Surveys Only