TOXICANTS IN HUMAN PLACENTAE AND REPRODUCTIVE OUTCOMES IN UKRAINE

工作总结：关于高环境污染和怀孕的大型研究只有几个。我们收集了乌克兰两个城市地区3000多名孕妇的数据。乌克兰是前苏联共和国，据说那里的污染很严重；我们在分娩和住院期间从其中2200名孕妇身上采集了胎盘和母乳。在过去的两年里，我们一直在分析这些数据。我们刚刚发表了关于母乳中有机氯和二恶英化合物水平的研究结果。我们还完成了一篇关于胎盘中多环芳烃的论文的最后草稿，并开始了对胎盘中四种金属的研究。总体而言，尽管有高污染的报告，但该样本中的毒物水平较低。一篇关于测量前东部地区污染的难度以及我们如何做到这一点的论文正在计划中。同时，我们描述了我们研究的女性所来自的人群的生育结果。我们已经完成了一篇关于两个城市样本中早产率的论文，并将继续检查低出生体重率。我们还将描述乌克兰城市怀孕期间的住院程序，这可能解释人口中一些值得注意的发现，如高胎儿损失率、低早产率和低出生体重。-东欧、东欧集团、生殖、怀孕、污染-人类主题

Summary of Work: There are only a few large studies of high environmental pollution and pregnancy. We have collected data on over 3,000 pregnant women in two urban areas of Ukraine, a former Soviet republic, where pollution is reputedly high; we took placentas and breast milk from 2,200 of them during delivery and hospitalization. We have been analyzing these data for the last two years. We have just published our findings on the levels of organochlorines and dioxin compounds in human milk. We have also completed the final draft of a paper on polycyclic aromatic hydrocarbons in placenta, and have begun the study of four metals in placenta. In general, the toxicants appear at low levels in this sample in spite of reports of high pollution. A paper on the difficulty of measuring pollution in the former eastern bloc and how we did it is planned. In parallel, we have described the reproductive outcome of the population from which the women we study were drawn. We have finished a paper on the rate of preterm birth in our sample in the two urban areas, and will continue with an examination of the rate of low birth weight. We will also describe hospitalization procedures during pregnancy in urban Ukraine, which may explain some of the notable findings in the population such as the high rate of fetal loss and the low rate of preterm birth and low birth weight. - Eastern Europe, eastern bloc, reproduction, pregnancy, pollution - Human Subjects