MAGNETIC FIELDS, MELATONIN AND CANCER

磁场影响乳腺癌风险的假设是基于磁场对褪黑激素影响的合理机制的存在以及一些有限的流行病学数据。这项研究有以下两个具体目标。1. 通过线路配置编码和直接测量来确定住宅暴露于磁场是否与乳腺癌风险有关。2. 第二种假设是，交流电磁场和直流电磁场的特定组合会增加患乳腺癌的风险。这一假设是由在几个实验系统中对交流和直流场的特定组合的生物效应的观察得出的。该研究是一项病例对照研究，嵌套在洛杉矶县约54,000名非洲裔和拉丁裔妇女的乳腺癌和其他癌症风险因素队列研究中。一名技术人员访问每个病例和对照组，进行测量，并对居住历史和夜间暴露于磁场和光线的来源（褪黑激素的一种效应）进行采访。在5年的研究期间，所有诊断出的乳腺癌病例都被纳入研究，我们估计有400-500例。正在登记相同数量的对照。我们已经完成了390多个病例和350个对照的登记，我们将继续登记到1999年11月。我们已经开始对磁场数据进行分析。我们将能够使用我们的问卷数据来检查影响褪黑激素稳态的因素——轮班工作和光照——与乳腺癌风险之间的关系。-电磁场，磁场，乳腺癌，激素，褪黑激素，非裔美国人，拉丁裔美国人-人类受试者：访谈，问卷调查或仅限调查

The hypothesis that magnetic fields influence breast cancer risk is based on the existence of a plausible mechanism related to the effect of magnetic fields on melatonin along with some limited epidemiologic data. The study has two following specific goals. 1. To determine if residential exposure to magnetic fields, as assessed by wiring configuration coding and direct measurements is associated with the risk of breast cancer. 2. A secondary hypothesis is that particular combinations of the alternating current (AC) magnetic field and the direct current (DC) magnetic field, increase the risk of breast cancer. This hypothesis was prompted by observations of biologic effects at particular combinations of the AC and DC fields in several experimental systems. The study is a case-control study nested within a cohort study of risk factors for breast and other cancers among approximately 54,000 African-American and Latino women in Los Angeles County. A technician visits each case and control to make measurements and administer an interview on residential history and sources of exposure to magnetic fields and light at night, an effector of melatonin. All cases of breast cancer diagnosed over the 5 year study period are being enrolled -- we estimate 400-500 cases. An equal number of controls are being enrolled. We have completed enrollment on over 390 cases and 350 controls and we will continue enrollment until November 1999. We have begun the analysis of the magnetic field data. We will be able to use our questionnaire data to examine the association between factors that influence melatonin homeostatis - shift work and light exposure - and breast cancer risk. - EMF, magnetic fields, breast cancer, hormones, melatonin, African-American, Latino - Human Subjects: Interview, Questionaires, or Surveys Only