ASSESSMENT OF LV VOLUME & FUNCTION BY REAL TIME 3-DIMENSIONAL ECHOCARDIOGRAPHY

左心室容积是心脏病患者预后的重要指标。虽然有几种方法可以评估LV容量，但大多数方法都有重要的内在局限性。实时三维超声心动图（RT 3D echo）是一种能够即时采集体积图像的新技术。本研究旨在验证使用RT 3D超声心动图快速计算LV容积，并确定其在心脏病患者中的有用性。最初，我们报告了25例患者的结果。在这些研究的过程中，很明显，大量患者的内镜边界定义不理想，无法进行可靠的体积计算。因此，我们决定修改方案，以包括EchoGen的注射，EchoGen是一种用于静脉注射的造影剂，可使左心室腔不透明，从而提高内膜边界分辨率。到目前为止，我们已经研究了86例注射造影剂的患者，获得了71例可评价的患者。在分析这些患者中RT 3D回波和MRI之间的相关性之前，我们将继续进行患者招募，以达到总计75例可评价患者。- 实时三维超声心动图（RT 3D echo）、磁共振成像（MRI）-人类受试者

Left ventricular (LV) volumes are important prognostic indices in patients with heart disease. Although several methods can evaluate LV volumes, most have important intrinsic limitations. Real-time three- dimensional echocardiography (RT3D echo) is a novel technique capable of instantaneous acquisition of volumetric images. This study was undertaken to validate rapid LV volume calculations with RT3D echo and to determine their usefulness in cardiac patients. Initially, we reported the results obtained in 25 patients. During the course of these studies, it was apparent that an important number of patients had suboptimal endocardial border definition to allow for reliable volume calculation. We therefore decided to modify the protocol to include the injection of EchoGen, a contrast agent for intravenous injection that opacifies the left ventricular cavity and thus enhances endocardial border resolution. We have so far studied 86 patients with contrast injection that have yielded 71 evaluable patients. We will continue with patient accrual to reach a total of 75 evaluable patients before analyzing the correlation between RT3D echo and MRI in these patients. - real-time three-dimensional echocardiography (RT3D echo), magnetic resonance imaging (MRI) - Human Subjects