Optical Sensor for LDL and HDL Cholesterol Determination

说明：（申请人摘要） 低密度脂蛋白胆固醇（LDL-C）和早产风险增加 冠心病是公认的。此外，水平的提高 LDL-C与正常水平的胆固醇可能会导致风险增加， 冠心病另一方面，高密度脂蛋白胆固醇 通常观察到HDL-C具有保护作用。即时胆固醇 目前市场上的测量试剂盒只能测量总胆固醇 内容他们不能量化低密度脂蛋白胆固醇（LDL-C） 和高密度脂蛋白胆固醇（HDL-C）。智能光 系统（IOS），与Karol E.沃森，联合主任 洛杉矶加州大学胆固醇和脂质管理中心 洛杉矶。寻求设计和建造一个低成本的单步。自校准 用于同时定量测定LDL-C的胆固醇传感器 和HDL-C。申报的传感器经过内部校准 以解释测量中的任何误差。创新的光学设计和 测定格式确保光学读取器的成本将为大约100美元， 每项测试费用约为二元。本试验中使用的校准程序 将使该传感器不受基质效应的影响，血清样本可以 直接测试。 拟定商业应用： IOS的胆固醇传感器预计将准确，即时，报告HDL-C和 LDL-C含量。 医疗机构和个人有望迅速接受这一点 实验室测试的低成本替代品。 此外，预计这一发展 技术将导致一系列积极的家庭健康系统和系统， 与患者的医疗提供者互动。

DESCRIPTION: (Applicant's abstract) The association between elevated levels of low-density lipoprotein cholesterol (LDL-C) and an increased risk of premature coronary heart disease is well established. Further, an increase in the level of LDL-C with normal levels of cholesterol can result in an increased risk for coronary heart disease. On the other hand, high-density lipoprotein cholesterol (HDL-C) is often observed to have a protective effect. The instant cholesterol measurement kits currently on the market can only measure the total cholesterol content. They cannot quantify the low-density lipoprotein cholesterol (LDL-C) and high-density liprotein cholesterol (HDL-C) separately. Intelligent Optical Systems (IOS), in collaboration with Dr. Karol E. Watson, Co-Director of the Cholesterol and Lipid Management Center at the Unversity of California, Los Angeles. seeks to design and construct a low-cost, single-step. self-calibrated cholesterol sensor for the simultaneous, quantitative determination of LDL-C and HDL-C from fresh human serum. The proposed sensor is internally calibrated to account for any errors in the measurement. The innovative optical design and assay format ensures that the cost of the optical reader will be about $100 and each test will cost about $2.00. The calibration procedures used in this assay will make this sensor immune to matrix effects, and serum samples can be directly tested. PROPOSED COMMERCIAL APPLICATION: IOS's cholesterol sensor is expected to accurately, and instantly, report the HDL-C and LDL-C content. Medical offices and individuals are expected to quickly embrace this low-cost alternative to lab testing. In addition, it is expected that the development of this technology will lead to a family of proactive home-health systems and systems that interact with the patient's medical provider.