Does statin use have a disease modifying effect in symptomatic knee osteoarthritis? A multicentre randomised, double-blind, placebo-controlled trial

骨关节炎(OA)是导致膝关节疼痛和残疾的主要原因。治疗仅限于减轻疼痛和改善功能：没有治疗减缓疾病进展，有症状的终末期骨性关节炎通过膝关节置换治疗。他汀类药物用于降低胆固醇水平，可能会影响膝骨性关节炎的结构进展。我们建议进行一项随机对照试验，以观察他汀类药物的使用是否会减缓膝骨性关节炎的进展，从而延迟或防止关节置换的需要。

Osteoarthritis (OA) is a major cause of knee pain and disability. Treatments are limited to reducing pain and improving function: no therapy slows disease progression, with symptomatic end-stage OA treated by knee replacement. Statins, a drug class used to lower cholesterol levels, may affect the structural progression in knee OA. We propose a randomised controlled trial to see if statin use slows the progression of knee OA, which would delay or prevent the need for joint replacement.