AMC OPERATIONS CENTER

该提案是为伯明翰亚拉巴马大学（UAB）的综合癌症中心生物统计部门提供服务，作为艾滋病相关恶性肿瘤临床试验联盟（AMC）的运营，统计和数据管理中心。 到目前为止，AMC已经招募了159名患者参与五项AMC方案。 最近有两项协议对患者增加开放。 另有9项议定书正在拟订中。AMC运营中心为AMC提供研究设计、样本量和分析等方面的统计专业知识;协调AMC的开发、提交、实施和分析;维护临床试验数据库;对研究数据进行统计分析;管理自由支配基金;并协调从AMC参与者处获取标本捐赠给艾滋病基金库。 在即将到来的资助期间，AMC运营中心计划在数据输入过程中增加扫描仪的使用;提高生物统计支持的水平;增加AMC网页的使用以传播信息;并为工作人员增加一名财务助理以管理自由裁量基金。

This proposal is for the Comprehensive Cancer Center Biostatistics Unit at the University of Alabama at Birmingham (UAB) to serve as the Operations, Statistical and Data Management Center for the AIDS-Associated Malignancies Clinical Trials Consortium (AMC). To date, the AMC has enrolled 159 patients on five AMC protocols. Two protocols have recently opened to patient accrual. An additional 9 protocols are under development. The AMC Operations Center provides statistical expertise to the AMC in the areas to study design, sample size, and analyses; coordinates the development, submission, conduct and analysis of AMC; maintains the database for the clinical trials; performs statistical analyses on study data; manages the Discretionary Fund; and coordinates the acquisition of specimens from AMC participants for donation to the AIDS Malignancy Bank. During the upcoming funding period, the AMC Operations Center plans to increase the use of scanners in the data entry process; increase the level of biostatistical support; increase the use of the AMC WEB page for the dissemination of information; and add a fiscal associate to the staff to manage the discretionary fund.