SPATIAL ANALYSIS IN CHILDREN WITH FOCAL BRAIN INJURY

描述：拟议的研究，一个为期五年的前瞻性纵向 研究，旨在研究空间分析的早期发展，这是 被认为涉及指定部件、配置和 部件和配置的集成。 具体目标是：1） 定义与早期损伤相关的缺陷模式; 2）查看 真实的时间空间分析的反应时研究; 3）检查 这些技能的纵向发展模式，在早期重点 4）观察跨域空间处理;以及4）扩展 以前的工作，通过应用功能磁共振成像协议，检查神经模式， 空间分析处理中的激活。 三种认知行为 研究和一个fMRI研究提出。 这些研究旨在扩大 申请人先前的调查结果显示左侧和右侧 儿童早期获得性脑病变具有相似的空间模式 分析缺陷的成年人与后来获得的左或右病变。 的 来自拟议研究的新信息将涉及对 额外的空间分析任务的大脑区域，以比较 空间信息的构建和感知， 早期局灶性损伤后神经组织的差异。

DESCRIPTION: The proposed research, a five-year prospective longitudinal study, aims to examine the early development of spatial analysis, which is considered to involve the ability to specify the parts, configuration, and the integration of parts and configurations. The specific aims are: 1) to define patterns of deficit associated with early injury; 2) to look at reaction time studies for spatial analysis in real time; 3) to examine longitudinal patterns of development in these skills after early focal injury; 4) to look at cross-domain spatial processing; and 4) to extend previous work by applying an fMRI protocol for examining patterns of neural activation in spatial analytic processing. Three cognitive-behavioral studies and one fMRI study are proposed. The studies aims to extend the previous findings from the applicants showing left and right-sided early-acquired brain lesions in children to have similar pattern of spatial analysis deficits to adults with later-acquired left or right lesions. The new information from the proposed research would concern description of extra spatial analysis tasks by brain region, with a view to comparing construction and perception of space information, and the examination of differences in neural organization following early focal injury.