A new hierarchy of mathematical models to quantify the role of ghrelin during cell invasion

Ghrelin是一种新近发现的生长因子，通过促进细胞侵袭来调节食欲和促进肿瘤生长。Ghrelin增强细胞侵袭的机制目前尚不清楚。这一创新项目将开发一系列新的多尺度数学模型，用于量化Ghrelin如何调节细胞行为(运动、增殖和死亡)，并提供对Ghrelin如何促进细胞侵袭的精确细节的洞察。该项目将展示基于Ghrelin的策略控制细胞侵袭的潜力。通过将食欲调节和肿瘤生长联系起来，该项目的结果将为澳大利亚在这一重要领域的卫生政策提供参考。

Ghrelin is a recently-discovered growth factor that regulates appetite and promotes tumour growth by enhancing cell invasion. The mechanisms by which ghrelin enhances cell invasion are, at present, unknown. This innovative project will develop a new hierarchy of multiscale mathematical models that will be used to quantify how ghrelin modulates cell behaviour (motility, proliferation and death) and provide insight into the precise details of how ghrelin promotes cell invasion. This project will demonstrate the potential for ghrelin-based strategies to control cell invasion. By linking appetite regulation and tumour growth, the outcomes from this project will inform Australian health policy in this important area.