STATISTICAL SUPPORT FOR NIEHS EXPERIMENTAL STUDIES

本合同的目的是提供统计和 计算专业知识和资源，以总结，分析和帮助 对进行的各种实验室动物实验数据的解释 国家环境健康科学研究所（NIEHS）。 这些 调查包括亚慢性研究，致癌实验， 和其他毒理学研究。 NIEHS亚慢性研究的评价包括提供统计学 生存分析、器官和体重、临床化学， 血液学和病理学观察结果，用于 选择长期致癌性实验的剂量。 的 承包商还通过以下方式为NIEHS生殖评估提供支持 连续育种项目和其他专题研究。 对于NIEHS长期研究，承包商负责 开发和维护毒理学数据统计软件 管理系统（TDMS）。 这包括开发和维护 分析肿瘤发病率和生存率的程序， 食物和水消耗以及体重增加的汇总统计。 的 承包商还负责维护历史数据库 控制肿瘤发病率。

The objectives of this contract are to provide statistical and computational expertise and resources to summarize, analyze, and aid in the interpretation of data from various laboratory animal experiments conducted by the National Institute of Environmental health Sciences (NIEHS). These investigations consist of subchronic studies, carcinogenesis experiments, and other toxicological studies. Evaluation of NIEHS subchronic studies consists of providing statistical analyses of survival, organ and body weights, clinical chemistry, hematology, and pathology observations, variables which are used in the selection of doses for long-term carcinogenicity experiments. The contractor also provides support to the NIEHS Reproductive Assessment by Continuous Breeding Project and other special studies. For NIEHS long=term studies, the contractor has responsibility for developing and maintaining statistical software for the Toxicology Data Management System (TDMS). This includes developing and maintaining programs for the analysis of tumor incidence and survival and providing summary statistics for food and water consumption and weight gain. The contractor is also responsible for maintaining a database on historical control tumor incidence.