GENETIC & DEMOGRAPHIC MANAGEMENT OF BREEDING COLONIES

本项目的目标是确定 母乳喂养与母乳喂养对胆汁酸代谢的营养规划 配方奶粉喂养和甲状腺激素水平的关系。 的 具体目的是检验以下假设：1）母乳喂养与 配方奶喂养对成年人胆汁酸代谢的影响 狒狒;和2）甲状腺素（T4）的营养规划， 三碘甲状腺原氨酸（T3）浓度介导的编程 胆汁酸形成的变量。 初步结果显示， 研究和其他研究小组的研究表明， 母乳喂养和配方奶喂养的区别在于 脂蛋白浓度、胆汁酸合成和动脉粥样硬化形成 狒狒和人类 拟议的研究将确定具体的 胆汁酸代谢中的基因由早期营养编程 以及甲状腺激素的潜在作用。 基因的表达可能 受到多种控制的影响，包括DNA甲基化， 转录因子或基因结构。 拟议的研究将 确定胆汁酸代谢中的特定基因， 通过早期营养和甲状腺的潜在作用 荷尔蒙 基因的表达可能受到多种控制的影响， 包括DNA甲基化、转录因子或基因结构。 在这项研究中，对受早期饮食影响的基因的鉴定将 为进一步研究其分子机制奠定了基础。 营养方案。

The goal of this project is to determine the mechanism of nutritional programming of bile acid metabolism by breast-feeding vs. formula-feeding and the relationship to thyroid hormone levels. The specific aims are to test the hypotheses that: 1) breast-feeding vs. formula-feeding differentially programs bile acid metabolism in adult baboons; and 2) nutritional programming of thyroxine (T4) and trilodothyronine (T3) concentrations mediates the programming of variables of bile acid formation. Results from our preliminary studies and from those of other groups of investigators have shown that breast-feeding vs. formula-feeding differentially programs lipoprotein concentrations, bile acid synthesis, and atherogenesis in baboons and humans. The proposed studies will identify the specific genes in bile acid metabolism that are programmed by early nutrition and the potential role of thyroid hormones. Expression of genes may be affected by multiple controls, including DNA methylation, transcription factors, or gene structure. The proposed studies will identify the specific genes in bile acid metabolism that are programmed by early nutrition and the potential role of thyroid hormones. Expression of genes may be affected by multiple controls, including DNA methylation, transcription factors, or gene structure. Identification of the genes affected by early diet in this study will provide a basis for future studies on the molecular mechanisms of nutritional programming.