BIFUNCTIONAL CHELATING AGENTS IN TUMOR LOCALIZATION

单克隆抗体技术允许特异性的 本发明涉及用于靶向癌细胞的抗体及其抗原。 双功能螯合剂是具有强金属的化合物 在一端具有螯合基团和能够 另一端与蛋白质结合。 当与单克隆抗体结合时 抗体，这些试剂作为肿瘤放射性金属的载体 面向. 在过去的几年里，我们创造了许多 新的实验室方法来制备和表征金属螯合物， 医疗用途。 质谱分析在增强我们的 提供螯合剂和相关物质的质量分析的方法 化合物.

Monoclonal antibody technology allows the specificity of an antibody for its antigen to be used in targeting cancer cells. Bifunctional chelating agents are compounds with a strong metal chelating group at one end and a reactive functional group capable of binding to proteins at the other. When conjugated to monoclonal antibodies, these agents act as carriers of radiometals for tumor targeting. Over the past several years, we have created a number of new laboratory methods to prepare and characterize metal chelates for medical use. Mass spectrometry has much to offer in augmenting our methods to provide mass analysis of chelating agents and related compounds.