REGIONAL MYOCARDIAL FLOW MEASUREMENT BY XRAY COMPUTED TOMOGRAPHY

我们开发了一个数学模型， 考虑造影剂的血管和EV传输的成分 介质，描述为：C（t）= c * ta * [e（-t/B）+ d * [e（-t/h）]，其中 C是造影剂浓度，t =时间，a、B和c是血管 伽马变量拟合参数，d和h描述血管外 组织对比度 在3头猪中，3个系列（间隔1.5分钟），20 每隔一次心跳获得的连续扫描， 电子束CT 在3个系列中的第一个期间， 将碘帕醇（0.33cc/kg）在2分钟内施用到右心房中， 4或8秒。 该模型与采样密度值拟合良好 与两个隔室中的造影剂处理有关。 这个型号的 心肌微循环指示剂稀释过程可能非常 可用于量化体内心肌的功能 微循环使用各种成像方法，如快速CT和 磁共振成像（使用合适的造影剂 螯合钆）。

We have developed a mathematical model which incorporates two components accounting for both vascular and EV transit of contrast media, described by: C(t) = c * ta * [e(-t/b) + d * [e(-t/h)], where C is contrast concentration, t = time, a, b, and c are vascular gamma-variate fit parameters, and d and h describe extravascular tissue contrast. In 3 pigs, 3 series (at 1.5 min intervals) of 20 sequential scans, acquired every other heart beat, were obtained with electron beam CT. During the first of the series of 3, a bolus of iopamidol (0.33 cc/kg) was administered into the right atrium over 2, 4, or 8 sec. The model fitted well the sampled density values pertaining to contrast handling in both compartments. This model of the myocardial microcirculatory indicator dilution process may be very useful to quantify the function of the in vivo myocardial microcirculation using various imaging methods such as fast CT and magnetic resonance imaging (with a suitable contrast agent such as chelated gadolinium).