NEURAL BASES OF PERCEPTUAL FILLING IN: VISUAL CORTEX

局灶性癫痫代谢损害的MRI和MRI研究 光谱学(惠特克基金会) 简介：高达20%的局灶性癫痫患者(约 在美国有40万人)对抗癫痫药物没有反应。 在这些难治的患者中，目前只有不到三分之一的人 被认为是切除卵巢的高效手术的候选人 重点是癫痫，因为术前评估费用很高， 不准确的，并且经常是侵入性的(因此有风险)。也有人认为， 癫痫发作可能导致脑组织继发性神经元功能障碍 远离主要的癫痫发作中心。 方法：使用定量MRSI(Core Project I)和MRI(Core 项目四)方法，确定MR措施的最佳组合 用于癫痫发作灶的定位。 结果：早期研究表明，结合1H MRSI 松弛测量法具有高度的敏感性和特异性。在其患者中 癫痫可通过手术、恢复正常新陈代谢和 在手术后一年观察组织中的MRI措施 术前发现继发性神经元功能障碍。 讨论：无创手术的高度敏感性和特异性 MRSI和MRI对致痫灶的定位可以 降低术前评估的成本和风险，并有资格 更多难治性患者寻求有效的手术治疗。当 实施磁头梯度线圈和快速成像(核心项目IV 和ii)，然后在4.1T下进行容量测量、扩散和灌注测量 将被例行地包括在议定书中。从这个完整的先生 协议，将确定最佳组合。

Metabolic Lesions in Focal Epilepsy Studied by MRI and Spectroscopy (Whitaker Foundation) Introduction: Up to 20% of focal epilepsy patients (about 400,000 in the USA) fail to respond to anti-epileptic medication. Fewer than one-third of these refractory patients are currently considered candidates for the highly effective surgery to resect the seizure focus because the presurgical evaluation is costly, inaccurate, and often invasive (thus risky). It is also thought that seizures may induce secondary neuronal dysfunction in brain tissue remote from the primary seizure focus. Methods: Using quantitative MRSI (Core Project I) and MRI (Core Project IV) methods, determine the optimal combination of MR measures for localization of the epileptogenic seizure focus. Results: Early studies indicate that a combination of 1H MRSI and relaxometry is highly sensitive and specific. In patients whose seizures are eliminated by surgery, recovery of normal metabolism and MRI measures has been observed one year after surgery in tissue with secondary neuronal dysfunction detected before the surgery. Discussion: The high sensitivity and specificity of noninvasive MRSI and MRI for localization of the epileptogenic seizure focus could reduce the cost and risk of presurgical evaluation and could qualify more refractory patients for effective surgical treatment. When the head gradient coil and rapid imaging are implemented (Core Projects IV and II), then volumetry, diffusion, and perfusion measurements at 4.1T will be routinely included in the protocol. From this full MR protocol, an optimal combination will be determined.