STREPTOCOCCAL INACTIVATOR IN HUMAN CHEMOATTRACTANTS

描述（改编自申请人摘要）：总体目标 本项目旨在了解A组的分子发病机制， 紧张 将高度重视测试C5a的影响 肽酶（SCPA）对链球菌引起三种感染的能力 动物模型 第二个非常重要的目标是确认SCPA 蛋白质可以诱导对感染的免疫力。 这个项目的新方向 是研究表面蛋白对运输的影响， 在受感染动物的淋巴组织中。 调查从 我们的实验室表明链球菌感染是一种复杂的， 多阶段过程。 多种因子的调节表达有助于 病原体的能力，以避免先天性和适应性免疫防御， 他们的主人。 了解C5a肽酶在微生物中的重要性 毒力将扩大研究人员对宿主-寄生虫的了解 关系。 最近严重并发症的重新出现， 在美国，10%的办公室会打电话给普通医疗机构， 国家与A组链球菌感染有关，强调 需要一种有效的疫苗来预防这些感染。 一个有广泛 有效、安全的疫苗可能来自对A组的研究 链球菌C5a肽酶。

DESCRIPTION (Adapted from the applicants abstract): The overall goal of this project is to understand the molecular pathogenesis of group A streptococcus. High priority will be given to testing the impact of the C5a peptidase (SCPA) on the capacity of streptococci to cause infection in three animal models. A second, very important objective is to confirm that SCPA protein can induce immunity to infection. A new direction of this project is to investigate the impact of surface proteins on the trafficking of streptococci to lymphoid tissues in infected animals. Investigations from our laboratory indicate that streptococcal infections are a complex, multi-stage process. Regulated expression of multiple factors contributes to a pathogen's capacity to avoid the innate and adaptive immune defenses of their host. Understanding the importance of C5a peptidases in microbial virulence will expand the investigators knowledge of host-parasite relationships. The recent resurgence of serious complications and the fact that 10% of all office calls in a general medical practice in the United States are associated with group A streptococcal infections, highlight the need for an effective vaccine to prevent these infections. A broadly effective, safe vaccine could result from this study of group A streptococcal C5a peptidase.