SYNTHESIS OF NEW TITANIUM, PLATINUM, AND RUTHENIUM ANTICANCER DRUGS

描述(改编自应用)：势的合成 抗癌药物，包括阿迪替酯和羧酸络合物 钛、铂、钚和铂的羧酸盐络合物 将尝试含有有机锡碎片。阿迪托利 络合物可以由相应的 氯代或碳酸盐与相应的烷醇的络合物。这个 羧酸盐络合物可以从以下反应中获得 相应的钠长石酸盐或碳酸盐络合物 羧酸。含铂的羧酸盐络合物 有机锡片段可以从以下两种反应中合成 相应的铂羧酸和相应的有机锡 氢氧化物或相应的有机锡羧酸。这个 钛、铂和钌的络合物将用紫外可见光谱表征 可见光谱、红外光谱和核磁共振光谱以及Ru的络合物将被 用紫外可见光谱、红外光谱、核磁共振光谱和元素分析对其进行了表征。 这些络合物的毒性水平将在约翰斯进行测量。 霍普金斯大学。这些化合物的细胞毒性和抗增殖作用 复合体将在南方研究中心的细胞系上进行测试 研究所。这个项目的长期目标是综合各种 钛、铂和Ru的羧酸络合物包含 有机锡碎片将导致广泛的发展范围 潜在的抗癌药物。

Description (Adapted from Application): Synthesis of potential anticancer drugs which include alditolate and carboxylate complexes of titanium, platinum, and ruthenium and carboxylate complexes of platinum containing organotin fragments will be attempted. The alditolate complexes may be synthesized from the reactions of the corresponding chloro or carbonate complexes with the corresponding alidotols. The carboxylate complexes may be obtained from the reactions of the corresponding alditolate or carbonate complexes with the corresponding carboxylic acids. The carboxylate complexes of platinum containing organotin fragment may be synthesized from the reactions of either the corresponding platinum carboxylic acids with the corresponding organotin hydroxides or the corresponding organotin carboxylic acids. The titanium, platinum, and ruthenium complexes will be characterized by UV- Vis, IR, and NMR spectra and by ruthenium complexes will be characterized by UV-Vis, IR, and NMR spectra and by elemental analysis. The levels of toxicity of these complexes will be measured at Johns Hopkins University. The cytotoxic and antiproliferative effects of these complexes will be tested on cell lines at the Southern Research Institute. The long-term goal of this project is to synthesize a variety of titanium, platinum, and ruthenium carboxylate complexes containing organotin fragments which will lead to the development of a broad range of potential anti-cancer drugs.